HEXIM2 antibody (N-Term)

Catalog No. ABIN2776632

Product Details anti-HEXIM2 Antibody

Target: HEXIM2 (Hexamthylene Bis-Acetamide Inducible 2 (HEXIM2))

Binding Specificity: N-Term

Reactivity: Human, Rat, Pig, Dog, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HEXIM2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MATPNQTACN AESPVALEEA KTSGAPGSPQ TPPERHDSGG SLPLTPRMES

Predicted Reactivity: Dog: 93%, Horse: 79%, Human: 100%, Pig: 86%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against HEXIM2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HEXIM2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 286 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HEXIM2

Target: HEXIM2 (Hexamthylene Bis-Acetamide Inducible 2 (HEXIM2))

Alternative Name: HEXIM2 (HEXIM2 Products)

Synonyms: 4933402L21Rik antibody, hexamethylene bisacetamide inducible 2 antibody, hexamethylene bis-acetamide inducible 2 antibody, HEXIM2 antibody, Hexim2 antibody

Background: HEXIM2 belongs to the HEXIM family. It is transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor.In cooperation with 7SK snRNA, HEXIM2 sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.
Alias Symbols: FLJ32384, L3
Protein Interaction Partner: TCF12, CCDC36, HEXIM2, PRDM14, RNPS1, TADA3, SPRY2, SPRY1, PIN1, PIM1, MEOX2, GATA1, CDK9, RN7SK, HEXIM1, TERF2, TERF1, MEPCE, CCNT1,
Protein Size: 286

Molecular Weight: 31 kDa

Gene ID: 124790

NCBI Accession: NM_144608, NP_653209

UniProt: Q96MH2