HRG antibody (Middle Region)

Catalog No. ABIN2776784

Product Details anti-HRG Antibody

Target: HRG (Histidine-Rich Glycoprotein (HRG))

Binding Specificity: Middle Region

Reactivity: Human, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HRG antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: EVLPLPEANF PSFPLPHHKH PLKPDNQPFP QSVSESCPGK FKSGFPQVSM

Predicted Reactivity: Human: 100%, Rabbit: 79%

Characteristics: This is a rabbit polyclonal antibody against HRG. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human HRG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 525 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HRG

Target: HRG (Histidine-Rich Glycoprotein (HRG))

Alternative Name: HRG (HRG Products)

Synonyms: AI265597 antibody, AW413091 antibody, D16jh2 antibody, D18020 antibody, Hprg antibody, Hrgp antibody, HPRG antibody, HRGP antibody, THPH11 antibody, HRG1 antibody, histidine rich glycoprotein antibody, histidine-rich glycoprotein antibody, HRG antibody, LOAG_12427 antibody, LOC100597044 antibody, Hrg antibody

Background: This histidine-rich glycoprotein(HRG) contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels.This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: DKFZp779H1622, HPRG, HRGP
Protein Interaction Partner: RCHY1, RABAC1, SPRY1, CHRD, TNFRSF1A, PLSCR1, FN1, THBS1, PLG, FCGR1A, FGA, C1QB, C1QA,
Protein Size: 525

Molecular Weight: 60 kDa

Gene ID: 3273

NCBI Accession: NM_000412, NP_000403

UniProt: P04196