DDC antibody (Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase)) (N-Term)

Details for Product anti-DDC Antibody No. ABIN2776802, Supplier: Log in to see
Antigen
  • 5-HT
  • AADC
  • CG10697
  • DDC
  • DdcDm
  • Dmel\\CG10697
  • ddc
  • fDDC
  • l(2)37Bl
  • l(2)37Ch
  • l(2)k02104
  • AMD-r
  • CG10501
  • CG17345
  • Dmel\\CG10501
  • X04695
  • fAMD
  • l(2)37Bk
  • l(2)amd
  • l(2)amd alpha-methyldopa hypersensitive
  • l(2)amd[H]
  • Ddc
  • DdcDv
  • Dvir\\GJ17995
  • GJ17995
  • dvir_GLEANR_2561
  • wu:fa56d05
  • wu:fd59h03
  • wu:fk20h01
  • zgc:65801
  • zgc:76929
  • Aadc
  • Dopa decarboxylase
  • alpha methyl dopa-resistant
  • dopa decarboxylase (aromatic L-amino acid decarboxylase)
  • dopa decarboxylase
  • Dopa-decarboxylase
  • Ddc
  • amd
  • DDC
  • ddc
  • Dvir\\Ddc
Alternatives
anti-Cow (Bovine) DDC antibody for Immunohistochemistry
Epitope
N-Term
40
25
19
15
15
5
2
1
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Rabbit, Rat (Rattus), Zebrafish
135
67
65
24
16
12
10
9
4
3
2
2
1
Host
Rabbit
94
36
16
3
1
Clonality
Polyclonal
Conjugate
This DDC antibody is un-conjugated
7
5
5
5
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
126
60
37
36
36
26
15
13
2
2
1
1
1
1
Options
Supplier
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Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human DDC
Sequence EFRRRGKEMV DYVANYMEGI EGRQVYPDVE PGYLRPLIPA AAPQEPDTFE
Predicted Reactivity Cow: 92%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 92%, Zebrafish: 92%
Characteristics This is a rabbit polyclonal antibody against DDC. It was validated on Western Blot and immunohistochemistry.
Purification Protein A purified
Alternative Name DDC (DDC Antibody Abstract)
Background DDC catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
Alias Symbols: AADC
Protein Interaction Partner: ATF6, RELA, AR,
Protein Size: 480
Molecular Weight 53 kDa
Gene ID 1644
NCBI Accession NM_000790, NP_000781
UniProt P20711
Pathways Dopaminergic Neurogenesis
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 480 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Supplier Images
Western Blotting (WB) image for anti-Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC) (N-Term) antibody (ABIN2776802) WB Suggested Anti-DDC Antibody Titration: 5.0ug/ml
Positive Control:
Immunohistochemistry (IHC) image for anti-Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC) (N-Term) antibody (ABIN2776802) anti-Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC) (N-Term) antibody (Image 2)
Product cited in: Shimohata, Ishihara, Hattori, Miyamoto, Morishita, Ornthanalai, Raveau, Ebrahim, Amano, Yamada, Sago, Akiba, Mataga, Murphy, Miyakawa, Yamakawa: "Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism." in: Experimental neurology, Vol. 293, pp. 1-12, 2017 (PubMed).

Background publications Ma, Beuten, Payne, Dupont, Elston, Li: "Haplotype analysis indicates an association between the DOPA decarboxylase (DDC) gene and nicotine dependence." in: Human molecular genetics, Vol. 14, Issue 12, pp. 1691-8, 2005 (PubMed).

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