MARCO antibody (C-Term)

Catalog No. ABIN2776891

Product Details anti-MARCO Antibody

Target: MARCO (Macrophage Receptor with Collagenous Structure (MARCO))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Horse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MARCO antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GPAGVKGEQG SPGLAGPKGA PGQAGQKGDQ GVKGSSGEQG VKGEKGERGE

Predicted Reactivity: Horse: 86%, Human: 100%, Mouse: 85%, Rat: 85%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against MARCO. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human MARCO

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 520 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MARCO

Target: MARCO (Macrophage Receptor with Collagenous Structure (MARCO))

Alternative Name: MARCO (MARCO Products)

Synonyms: AI323439 antibody, Ly112 antibody, Scara2 antibody, SCARA2 antibody, macrophage receptor with collagenous structure antibody, MARCO antibody, Marco antibody

Background: The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains.
Alias Symbols: SCARA2
Protein Interaction Partner: SCGB3A2, SCGB3A1,
Protein Size: 520

Molecular Weight: 53 kDa

Gene ID: 8685

NCBI Accession: NM_006770, NP_006761

UniProt: Q9UEW3

Pathways: Activation of Innate immune Response