FAH antibody (C-Term)

Catalog No. ABIN2776935

Product Details anti-FAH Antibody

Target: FAH (Fumarylacetoacetate Hydrolase (Fumarylacetoacetase) (FAH))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Dog, Horse, Cow, Guinea Pig, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FAH antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: AATICKSNFK YMYWTMLQQL THHSVNGCNL RPGDLLASGT ISGPEPENFG

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against FAH. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human FAH

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 419 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-FAH antibody (ABIN2776935)

Calattini, Fusil, Mancip, Dao Thi, Granier, Gadot, Scoazec, Zeisel, Baumert, Lavillette, Dreux, Cosset: "Functional and Biochemical Characterization of Hepatitis C Virus (HCV) Particles Produced in a Humanized Liver Mouse Model." in: The Journal of biological chemistry, Vol. 290, Issue 38, pp. 23173-87, (2015) (PubMed).

Hu, Lausted, Yoo, Yan, Brightman, Chen, Wang, Bu, Hood: "Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity." in: Theranostics, Vol. 4, Issue 2, pp. 215-28, (2014) (PubMed).

Target Details for FAH

Target: FAH (Fumarylacetoacetate Hydrolase (Fumarylacetoacetase) (FAH))

Alternative Name: FAH (FAH Products)

Synonyms: CG14993 antibody, Dmel\\CG14993 antibody, dfaa antibody, l(3)64Al antibody, l(3)SH11 antibody, PSPTO3550 antibody, fb59b12 antibody, wu:fb59b12 antibody, zgc:55316 antibody, FAA antibody, Fumarylacetoacetase antibody, FumarylAcetoacetate Hydrolase antibody, fumarylacetoacetase antibody, fumarylacetoacetate hydrolase antibody, fumarylacetoacetate hydrolase (fumarylacetoacetase) antibody, fumarylacetoacetate hydrolase (fumarylacetoacetase) L homeolog antibody, Faa antibody, fah-1 antibody, fahA antibody, hmgB antibody, Ndas_1870 antibody, Lbys_3503 antibody, Riean_0663 antibody, Ftrac_0820 antibody, Celal_3675 antibody, Celly_2655 antibody, Weevi_0208 antibody, Fluta_2435 antibody, Halhy_2019 antibody, Lacal_2931 antibody, FsymDg_1892 antibody, Fah antibody, fah antibody, fah.L antibody, FAH antibody

Background: FAH is the last enzyme in the tyrosine catabolism pathway. FAH deficiency is associated with Type 1 hereditary tyrosinemia.This gene encodes the last enzyme in the tyrosine catabolism pathway. FAH deficiency is associated with Type 1 hereditary tyrosinemia (HT).
Protein Interaction Partner: KRTAP10-8, ADAMTSL4, SERTAD1, TCF4, KRTAP5-9, UBC, EGFR,
Protein Size: 419

Molecular Weight: 46 kDa

Gene ID: 2184

NCBI Accession: NM_000137, NP_000128

UniProt: P16930