Amylin/DAP antibody (N-Term)
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- Target See all Amylin/DAP (IAPP) Antibodies
- Amylin/DAP (IAPP) (Islet Amyloid Polypeptide (IAPP))
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Binding Specificity
- N-Term
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Reactivity
- Human, Rabbit, Dog, Cow, Horse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Amylin/DAP antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- MGILKLQVFL IVLSVALNHL KATPIESHQV EKRKCNTATC ATQRLANFLV
- Predicted Reactivity
- Cow: 82%, Dog: 86%, Horse: 93%, Human: 100%, Rabbit: 86%
- Characteristics
- This is a rabbit polyclonal antibody against IAPP. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human IAPP
- Top Product
- Discover our top product IAPP Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 89 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- Amylin/DAP (IAPP) (Islet Amyloid Polypeptide (IAPP))
- Alternative Name
- IAPP (IAPP Products)
- Synonyms
- DAP antibody, IAP antibody, LOC100230121 antibody, Amylin antibody, islet amyloid polypeptide antibody, IAPP antibody, Iapp antibody
- Background
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Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the assosciation of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Studies suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes.
Alias Symbols: AMYLIN, DAP, IAP
Protein Interaction Partner: COL25A1, RAMP2, RAMP1, PDX1, PCSK2, PCSK1,
Protein Size: 89 - Molecular Weight
- 4 kDa
- Gene ID
- 3375
- NCBI Accession
- NM_000415, NP_000406
- UniProt
- P10997
- Pathways
- Hormone Activity, Feeding Behaviour
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