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CRH antibody (C-Term)

CRH Reactivity: Human, Rat, Mouse, Dog, Pig, Sheep, Cow, Rabbit, Guinea Pig, Zebrafish (Danio rerio) WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2776995
  • Target See all CRH Antibodies
    CRH (Corticotropin Releasing Hormone (CRH))
    Binding Specificity
    • 15
    • 15
    • 11
    • 8
    • 6
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 76
    • 51
    • 49
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Rat, Mouse, Dog, Pig, Sheep, Cow, Rabbit, Guinea Pig, Zebrafish (Danio rerio)
    Host
    • 84
    • 18
    • 2
    • 2
    Rabbit
    Clonality
    • 90
    • 16
    Polyclonal
    Conjugate
    • 43
    • 14
    • 12
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    This CRH antibody is un-conjugated
    Application
    • 81
    • 36
    • 29
    • 26
    • 26
    • 14
    • 9
    • 8
    • 6
    • 6
    • 5
    • 2
    • 2
    Western Blotting (WB)
    Sequence
    GGHQEAPERE RRSEEPPISL DLTFHLLREV LEMARAEQLA QQAHSNRKLM
    Predicted Reactivity
    Cow: 85%, Dog: 100%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 92%, Zebrafish: 93%
    Characteristics
    This is a rabbit polyclonal antibody against CRH. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C-terminal region of Human CRH
    Top Product
    Discover our top product CRH Primary Antibody
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeat freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    CRH (Corticotropin Releasing Hormone (CRH))
    Alternative Name
    CRH (CRH Products)
    Synonyms
    CRF antibody, Gm1347 antibody, crf antibody, crh antibody, zgc:101864 antibody, CRH antibody, corticoliberin antibody, crhb antibody, crh.1-a antibody, crha antibody, corticotropin releasing hormone antibody, corticotropin releasing hormone b antibody, corticotropin releasing hormone S homeolog antibody, corticotropin releasing hormone L homeolog antibody, Crh antibody, CRH antibody, crhb antibody, crh antibody, crh.S antibody, crh.L antibody
    Background
    Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition.
    Alias Symbols: CRF
    Protein Interaction Partner: KRT31, CRHR1, CRH, CRHR2,
    Protein Size: 196
    Molecular Weight
    21 kDa
    Gene ID
    1392
    NCBI Accession
    NM_000756, NP_000747
    UniProt
    P06850
    Pathways
    Positive Regulation of Peptide Hormone Secretion, Hormone Activity, Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Feeding Behaviour
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