TNNI1 antibody (Middle Region)

Catalog No. ABIN2777152

Product Details anti-TNNI1 Antibody

Target: TNNI1 (Slow Skeletal Troponin I (TNNI1))

Binding Specificity: Middle Region

Reactivity: Human, Rat, Mouse, Cow, Goat, Guinea Pig, Zebrafish (Danio rerio), Horse, Rabbit, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNNI1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PPLRRVRVSA DAMLRALLGS KHKVSMDLRA NLKSVKKEDT EKERPVEVGD

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against TNNI1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TNNI1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 187 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TNNI1

Target: TNNI1 (Slow Skeletal Troponin I (TNNI1))

Alternative Name: TNNI1 (TNNI1 Products)

Synonyms: ANM antibody, NEM5 antibody, STNT antibody, TNT antibody, TNTS antibody, TnI-S4 antibody, SSTNI antibody, TNN1 antibody, 2700018B22Rik antibody, AI747285 antibody, ssTnI antibody, AW146156 antibody, Tnt antibody, sTnT antibody, ssTnT antibody, Fang2 antibody, tnTs antibody, troponin 1 antibody, zgc:86895 antibody, troponin T1, slow skeletal type antibody, troponin I1, slow skeletal type antibody, troponin I, skeletal, slow 1 antibody, troponin T1, skeletal, slow antibody, troponin I1, slow skeletal type S homeolog antibody, troponin I type 1 (skeletal, slow) antibody, troponin I4b, tandem duplicate 2 antibody, TNNT1 antibody, TNNI1 antibody, Tnni1 antibody, Tnnt1 antibody, tnni1.S antibody, tnni4b.2 antibody

Background: Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Each troponin-tropomyosin complex contains 1 Molecule from each of the 3 troponins: T, C, and I. The troponin I (TNI) subfamily contains three genes: TNI-skeletal-fast-twitch, TNI-skeletal-slow-twitch, and TNI-cardiac. TNNI1 prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes.
Alias Symbols: DKFZp451O223, SSTNI, TNN1
Protein Interaction Partner: PNMA1, MDFI, TRIM63, TRIM55, TNNC1, TNNT2, EIF3I, CCDC85B, TNNT1, ACTA1, PKD2L1,
Protein Size: 187

Molecular Weight: 21 kDa

Gene ID: 7135

NCBI Accession: NM_003281, NP_003272

UniProt: P19237