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STAT6 antibody (C-Term)

STAT6 Reactivity: Human, Mouse, Rat, Dog, Cow, Rabbit, Horse, Guinea Pig WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2777200
  • Target See all STAT6 Antibodies
    STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))
    Binding Specificity
    • 34
    • 16
    • 13
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 132
    • 70
    • 59
    • 10
    • 9
    • 6
    • 6
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Dog, Cow, Rabbit, Horse, Guinea Pig
    Host
    • 112
    • 19
    • 4
    • 1
    Rabbit
    Clonality
    • 100
    • 35
    Polyclonal
    Conjugate
    • 77
    • 7
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This STAT6 antibody is un-conjugated
    Application
    • 70
    • 44
    • 42
    • 27
    • 26
    • 26
    • 25
    • 19
    • 16
    • 11
    • 8
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    NLYPKKPKDE AFRSHYKPEQ MGKDGRGYVP ATIKMTVERD QPLPTPELQM
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
    Characteristics
    This is a rabbit polyclonal antibody against STAT6. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human STAT6
    Top Product
    Discover our top product STAT6 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 847 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))
    Alternative Name
    STAT6 (STAT6 Products)
    Synonyms
    D12S1644 antibody, IL-4-STAT antibody, STAT6B antibody, STAT6C antibody, signal transducer and activator of transcription 6 antibody, signal transducer and activator of transcription 6-like antibody, STAT6 antibody, Stat6 antibody, LOC100859543 antibody
    Background
    Full-length human STAR6 (NP_003144) was expressed in E.coli as inclusion body and purified after protein refolding for mouse immunization. Clone 5B1 shows excellent western blot detection of endogenous STAT6 using ACHN cell lysate.The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: D12S1644, IL-4-STAT, STAT6B, STAT6C
    Protein Interaction Partner: UBC, IRF4, PDE12, EHD1, USP8, API5, PGGT1B, EP300, TRIM28, JAK3, RCN3, LITAF, IL4R, EEF1A1, VKORC1, PTPN2, STAT2, JAK1, IFNG, IFNAR1, SRXN1, PSAT1, DSTN, SEC24A, AHCYL1, SSSCA1, NUBP2, SH3BGRL, RAD23B, PPM1G, IGBP1, CEBPE, SND1, SUMO2, FCER2, SFPQ, IGHE,
    Protein Size: 847
    Molecular Weight
    94 kDa
    Gene ID
    6778
    NCBI Accession
    NM_003153, NP_003144
    UniProt
    P42226
    Pathways
    JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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