IRF9 antibody (N-Term)

Catalog No. ABIN2777226

Product Details anti-IRF9 Antibody

Target: IRF9 (Interferon Regulatory Factor 9 (IRF9))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Zebrafish (Danio rerio), Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRF9 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: PWKHAGKQDF REDQDAAFFK AWAIFKGKYK EGDTGGPAVW KTRLRCALNK

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against ISGF3G. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ISGF3G

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 393 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-IRF9 antibody (ABIN2777226)

Bidwell, Slaney, Withana, Forster, Cao, Loi, Andrews, Mikeska, Mangan, Samarajiwa, de Weerd, Gould, Argani, Möller, Smyth, Anderson, Hertzog, Parker: "Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape." in: Nature medicine, Vol. 18, Issue 8, pp. 1224-31, (2013) (PubMed).

Schumacher, Lau, Johnson: "Structural basis of core promoter recognition in a primitive eukaryote." in: Cell, Vol. 115, Issue 4, pp. 413-24, (2003) (PubMed).

Target Details for IRF9

Target: IRF9 (Interferon Regulatory Factor 9 (IRF9))

Alternative Name: ISGF3G (IRF9 Products)

Synonyms: IRF-9 antibody, ISGF3 antibody, ISGF3G antibody, p48 antibody, zgc:92097 antibody, Irf-9 antibody, Isgf3g antibody, interferon regulatory factor 9 antibody, IRF9 antibody, irf9 antibody, Irf9 antibody

Background: ISGF3G functions to recruit RNA polymerase II to the promoter of interferon-stimulated genes and requires histone deacetylases. Defects in ISGF3 can cause resistance to IFN-.(2a) treatment.
Alias Symbols: IRF-9, ISGF3, ISGF3G, p48
Protein Interaction Partner: S100A13, MYO1F, TOP1, IRF1, IRF2BP1, DNMT3A, ELAVL1, STAT2, IFNAR2, CREBBP, DACH2, DMRTC2, TLX3, VENTX, ARID3B, NR2E3, POU2F1, HOXC9, TLX2, STAT1, IFNA1, RELA, NFKB1,
Protein Size: 393

Molecular Weight: 44 kDa

Gene ID: 10379

NCBI Accession: NM_006084, NP_006075

UniProt: Q00978

Pathways: JAK-STAT Signaling, Interferon-gamma Pathway, Hepatitis C