TAL1 antibody (N-Term)

Catalog No. ABIN2777291

Product Details anti-TAL1 Antibody

Target: TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Dog, Cow, Rabbit, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TAL1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: TERPPSEAAR SDPQLEGRDA AEASMAPPHL VLLNGVAKET SRAAAAEPPV

Predicted Reactivity: Cow: 85%, Dog: 85%, Human: 100%, Mouse: 92%, Pig: 92%, Rabbit: 92%, Rat: 85%

Characteristics: This is a rabbit polyclonal antibody against TAL1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TAL1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 331 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-TAL1 antibody (ABIN2777291)

Hosur, Cox, Burzenski, Riding, Alley, Lyons, Kavirayani, Martin, Cox, Johnson, Shultz: "Retrotransposon insertion in the T-cell acute lymphocytic leukemia 1 (Tal1) gene is associated with severe renal disease and patchy alopecia in Hairpatches (Hpt) mice." in: PLoS ONE, Vol. 8, Issue 1, pp. e53426, (2013) (PubMed).

Target Details for TAL1

Target: TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))

Alternative Name: TAL1 (TAL1 Products)

Synonyms: SCL/tal-1 antibody, Scl antibody, bHLHa17 antibody, tal-1 antibody, SCL antibody, TCL5 antibody, scl antibody, tcl5 antibody, SCL-alpha antibody, SCL-beta antibody, scl/tal1 antibody, zgc:85605 antibody, T cell acute lymphocytic leukemia 1 antibody, TAL bHLH transcription factor 1, erythroid differentiation factor antibody, T-cell acute lymphocytic leukemia 1 S homeolog antibody, T-cell acute lymphocytic leukemia 1 antibody, Tal1 antibody, TAL1 antibody, tal1.S antibody, tal1 antibody

Background: TAL1 is implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. It also serves as a positive regulator of erythroid differentiation
Alias Symbols: SCL, TCL5, tal-1, bHLHa17
Protein Interaction Partner: ELSPBP1, SIN3A, KAT2B, EP300, HOXB9, DRG1, CHD3, ZHX1, STUB1, UBC, RB1, SSBP2, SSBP3, RCOR1, KDM1A, LDB1, TCF12, TCF3, RBBP7, LYL1, HDAC2, HDAC1, CHD4, CBFA2T3, RUNX1, SUPT16H, TAL1, CDK9, TRIM33, SUV39H1, SATB1, TRIM27, NCAPG2, MAPK3, SP1, LMO1, LMO2, GA
Protein Size: 331

Molecular Weight: 34 kDa

Gene ID: 6886

NCBI Accession: NM_003189, NP_003180

UniProt: P17542

Pathways: Stem Cell Maintenance