Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

ATF6B antibody (Middle Region)

ATF6B Reactivity: Human, Mouse, Rat, Pig, Cow, Horse, Dog WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2777358
  • Target See all ATF6B Antibodies
    ATF6B (Activating Transcription Factor 6 beta (ATF6B))
    Binding Specificity
    • 15
    • 8
    • 7
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 32
    • 28
    • 9
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Pig, Cow, Horse, Dog
    Host
    • 46
    • 1
    Rabbit
    Clonality
    • 46
    • 1
    Polyclonal
    Conjugate
    • 16
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This ATF6B antibody is un-conjugated
    Application
    • 40
    • 23
    • 13
    • 13
    • 6
    • 4
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Sequence
    FNRTESLRLA DELSGWVQRH QRGRRKIPQR AQERQKSQPR KKSPPVKAVP
    Predicted Reactivity
    Cow: 86%, Dog: 93%, Horse: 93%, Human: 100%, Mouse: 86%, Pig: 85%, Rat: 86%
    Characteristics
    This is a rabbit polyclonal antibody against CREBL1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human CREBL1
    Top Product
    Discover our top product ATF6B Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 703 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    ATF6B (Activating Transcription Factor 6 beta (ATF6B))
    Alternative Name
    CREBL1 (ATF6B Products)
    Synonyms
    CREBL1 antibody, CREB-RP antibody, G13 antibody, AA617266 antibody, ATF6beta antibody, Creb-rp antibody, Crebl1 antibody, activating transcription factor 6 beta antibody, cyclic AMP-dependent transcription factor ATF-6 beta antibody, ATF6B antibody, LOC745411 antibody, Atf6b antibody
    Background
    ATF6B(CREBL1) is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. ATF6B is normally found in the membrane of the endoplasmic reticulum, however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene.The protein encoded by this gene bears sequence similarity with the Creb/ATF subfamily of the bZip superfamily of transcription factors. It localizes to both the cytoplasm and the nucleus. The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: CREB-RP, FLJ10066, G13, CREBL1
    Protein Interaction Partner: CREBZF, XBP1, ATF6B, CDK6, UBC, SUMO2, ATF6, NFYC, MBTPS1, PHOX2A, MBTPS2, NFYA, HCVgp1,
    Protein Size: 703
    Molecular Weight
    77 kDa
    Gene ID
    1388
    NCBI Accession
    NM_004381, NP_004372
    UniProt
    Q99941
    Pathways
    Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction
You are here:
Support