Paired-Like Homeobox 2a (PHOX2A) (N-Term) antibody

Details for Product No. ABIN2777426, Supplier: Log in to see
Antigen
  • ARIX
  • CFEOM2
  • FEOM2
  • NCAM2
  • PMX2A
  • Arix
  • Phox2
  • Pmx2
  • Pmx2a
  • arix
  • sou
  • zgc:77364
  • phox2
  • xphox2a
  • paired-like homeobox 2a
  • PHOX2A
  • Phox2a
  • phox2a
Epitope
N-Term
9
8
4
4
4
3
3
2
2
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Rabbit, Rat (Rattus), Zebrafish
65
29
28
9
9
7
6
5
5
3
1
1
Host
Rabbit
36
15
14
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
49
31
13
11
9
7
5
3
2
1
1
1
1
Options
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Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human PHOX2A
Blocking Peptide Blocking peptide for this product available: ABIN981708
Sequence AVPYKFFPEP SGLHEKRKQR RIRTTFTSAQ LKELERVFAE THYPDIYTRE
Predicted Reactivity Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%
Characteristics This is a rabbit polyclonal antibody against PHOX2A. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name PHOX2A (PHOX2A Antibody Abstract)
Background PHOX2A contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. PHOX2A has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene.The protein encoded by this gene contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. The encoded protein has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene. Mutations in this gene have been associated with autosomal recessive congenital fibrosis of the extraocular muscles. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ARIX, CFEOM2, FEOM2, MGC52227, NCAM2, PMX2A
Protein Interaction Partner: SP1, PHOX2A, HAND2, PRKACA, ATF6B, CREBBP, JUN,
Protein Size: 284
Molecular Weight 30 kDa
Gene ID 401
NCBI Accession NM_005169, NP_005160
UniProt O14813
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 284 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Supplier Images
Immunohistochemistry (IHC) image for anti-Paired-Like Homeobox 2a (PHOX2A) (N-Term) antibody (ABIN2777426) Immunohistochemistry with Testis tissue at an antibody concentration of 5µg/ml using ...
Background publications Imai, Matsuo, Itoshima, Ohtsuki: "Clinical features, ARIX and PHOX2B nucleotide changes in three families with congenital superior oblique muscle palsy." in: Acta medica Okayama, Vol. 62, Issue 1, pp. 45-53, 2008 (PubMed).

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