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PHOX2A antibody (N-Term)

PHOX2A Reactivity: Human, Rat, Mouse, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio) WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2777426
  • Target See all PHOX2A Antibodies
    PHOX2A (Paired-Like Homeobox 2a (PHOX2A))
    Binding Specificity
    • 15
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 31
    • 7
    • 6
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    Human, Rat, Mouse, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)
    Host
    • 27
    • 3
    • 1
    Rabbit
    Clonality
    • 29
    • 2
    Polyclonal
    Conjugate
    • 13
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PHOX2A antibody is un-conjugated
    Application
    • 25
    • 13
    • 13
    • 11
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    AVPYKFFPEP SGLHEKRKQR RIRTTFTSAQ LKELERVFAE THYPDIYTRE
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%
    Characteristics
    This is a rabbit polyclonal antibody against PHOX2A. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human PHOX2A
    Top Product
    Discover our top product PHOX2A Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 284 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    PHOX2A (Paired-Like Homeobox 2a (PHOX2A))
    Alternative Name
    PHOX2A (PHOX2A Products)
    Synonyms
    ARIX antibody, CFEOM2 antibody, FEOM2 antibody, NCAM2 antibody, PMX2A antibody, Arix antibody, Phox2 antibody, Pmx2 antibody, Pmx2a antibody, arix antibody, sou antibody, zgc:77364 antibody, phox2 antibody, xphox2a antibody, paired like homeobox 2a antibody, paired-like homeobox 2a antibody, paired like homeobox 2a S homeolog antibody, PHOX2A antibody, Phox2a antibody, phox2a antibody, phox2a.S antibody
    Background
    PHOX2A contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. PHOX2A has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene.The protein encoded by this gene contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. The encoded protein has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene. Mutations in this gene have been associated with autosomal recessive congenital fibrosis of the extraocular muscles. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: ARIX, CFEOM2, FEOM2, MGC52227, NCAM2, PMX2A
    Protein Interaction Partner: SP1, PHOX2A, HAND2, PRKACA, ATF6B, CREBBP, JUN,
    Protein Size: 284
    Molecular Weight
    30 kDa
    Gene ID
    401
    NCBI Accession
    NM_005169, NP_005160
    UniProt
    O14813
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