TOLLIP antibody (C-Term)

Catalog No. ABIN2777431

Product Details anti-TOLLIP Antibody

Target: TOLLIP (Toll Interacting Protein (TOLLIP))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Zebrafish (Danio rerio), Cow, Guinea Pig, Horse, Rabbit, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TOLLIP antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MATTVSTQRG PVYIGELPQD FLRITPTQQQ RQVQLDAQAA QQLQYGGAVG

Predicted Reactivity: Cow: 85%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 83%, Rat: 100%, Yeast: 79%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against TOLLIP. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human TOLLIP

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 274 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-TOLLIP antibody (ABIN2777431)

Schimming, Parwez, Petrasch-Parwez, Nothnagel, Epplen, Hoffjan: "Association of toll-interacting protein gene polymorphisms with atopic dermatitis." in: BMC dermatology, Vol. 7, pp. 3, (2007) (PubMed).

Target Details for TOLLIP

Target: TOLLIP (Toll Interacting Protein (TOLLIP))

Alternative Name: TOLLIP (TOLLIP Products)

Synonyms: IL-1RAcPIP antibody, 4930403G24Rik antibody, 4931428G15Rik antibody, fk22a02 antibody, im:7145391 antibody, wu:fk22a02 antibody, zgc:76985 antibody, TOLLIP antibody, GB17961 antibody, tollip antibody, tollip1 antibody, tollipa antibody, TOLIP antibody, toll interacting protein antibody, toll-interacting protein antibody, toll-interacting protein-like antibody, toll interacting protein L homeolog antibody, toll interacting protein S homeolog antibody, Toll-interleukine I receptor interacting protein I antibody, TOLLIP antibody, Tollip antibody, tollip antibody, LOC552034 antibody, LOC100169858 antibody, tollip.L antibody, tollip.S antibody, LOC100136122 antibody

Background: TOLLIP is component of the signaling pathway of IL-1 and Toll-like receptors. It Inhibits cell activation by microbial products. It also recruits IRAK1 to the IL-1 receptor complex and inhibits IRAK1 phosphorylation and kinase activity.
Alias Symbols: FLJ33531, IL-1RAcPIP
Protein Interaction Partner: RBPMS, TOM1, DAZAP2, UBC, SIAH1, PRR20A, WDYHV1, CPSF6, DAB1, ATG8, MAP1LC3A, SQSTM1, NBR1, VPS35, OXR1, VPS29, CYHR1, NMI, APEH, RHOXF2, TOM1L1, IRAK1, PINK1, INTS4P2, SNX8, TRIP6, UBD, TGFBR1, ATXN1, SMAD7, TOM1L2, TOLLIP, GGA1, GGA3, GGA2, TRAF6, RAC1,
Protein Size: 274

Molecular Weight: 30 kDa

Gene ID: 54472

NCBI Accession: NM_019009, NP_061882

UniProt: Q9H0E2