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Metabotropic Glutamate Receptor 6 antibody (Middle Region)

GRM6 Reactivity: Human, Rat, Mouse, Dog, Rabbit, Cow, Guinea Pig, Horse, Zebrafish (Danio rerio), Pig WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2777489
  • Target See all Metabotropic Glutamate Receptor 6 (GRM6) Antibodies
    Metabotropic Glutamate Receptor 6 (GRM6) (Glutamate Receptor, Metabotropic 6 (GRM6))
    Binding Specificity
    • 14
    • 6
    • 6
    • 6
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 48
    • 17
    • 16
    • 6
    • 6
    • 5
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Rat, Mouse, Dog, Rabbit, Cow, Guinea Pig, Horse, Zebrafish (Danio rerio), Pig
    Host
    • 47
    • 3
    Rabbit
    Clonality
    • 48
    • 2
    Polyclonal
    Conjugate
    • 27
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Metabotropic Glutamate Receptor 6 antibody is un-conjugated
    Application
    • 36
    • 25
    • 13
    • 5
    • 5
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    EFWEENFNCK LTSSGTQSDD STRKCTGEER IGRDSTYEQE GKVQFVIDAV
    Predicted Reactivity
    Cow: 93%, Dog: 100%, Guinea Pig: 87%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 87%, Rat: 93%, Zebrafish: 93%
    Characteristics
    This is a rabbit polyclonal antibody against GRM6. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human GRM6
    Top Product
    Discover our top product GRM6 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 877 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    Metabotropic Glutamate Receptor 6 (GRM6) (Glutamate Receptor, Metabotropic 6 (GRM6))
    Alternative Name
    GRM6 (GRM6 Products)
    Synonyms
    mGluR6 antibody, CSNB1B antibody, GPRC1F antibody, MGLUR6 antibody, mGlu6 antibody, GRM6 antibody, BC021919 antibody, Gm3 antibody, Gprc1f antibody, nerg1 antibody, nob2 antibody, nob3 antibody, nob4 antibody, si:dkey-52h10.3 antibody, cb496 antibody, grma antibody, zK13A21.16 antibody, zgc:158329 antibody, glutamate metabotropic receptor 6 antibody, glutamate receptor, metabotropic 6 antibody, glutamate receptor, metabotropic 6a antibody, glutamate receptor, metabotropic 6b antibody, Grm6 antibody, GRM6 antibody, grm6a antibody, grm6b antibody
    Background
    GRM6 is the receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
    Alias Symbols: CSNB1B, DKFZp686H1993, GPRC1F, MGLUR6, mGlu6
    Protein Interaction Partner: GNAO1,
    Protein Size: 877
    Molecular Weight
    95 kDa
    Gene ID
    2916
    NCBI Accession
    NM_000843, NP_000834
    UniProt
    O15303
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