PIAS3 antibody (Middle Region)
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- Target See all PIAS3 Antibodies
- PIAS3 (Protein Inhibitor of Activated STAT, 3 (PIAS3))
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Binding Specificity
- Middle Region
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Reactivity
- Human, Rat, Dog, Cow, Horse, Guinea Pig, Rabbit
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PIAS3 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- DEIQFMEDGS WCPMKPKKEA SEVCPPPGYG LDGLQYSPVQ GGDPSENKKK
- Predicted Reactivity
- Cow: 79%, Dog: 86%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Rabbit: 79%, Rat: 79%
- Characteristics
- This is a rabbit polyclonal antibody against PIAS3. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human PIAS3
- Top Product
- Discover our top product PIAS3 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 628 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- PIAS3 (Protein Inhibitor of Activated STAT, 3 (PIAS3))
- Alternative Name
- PIAS3 (PIAS3 Products)
- Synonyms
- PIAS3 antibody, Pias3l antibody, ZMIZ5 antibody, protein inhibitor of activated STAT 3 antibody, protein inhibitor of activated STAT, 3 antibody, protein inhibitor of activated STAT 3 L homeolog antibody, PIAS3 antibody, pias3 antibody, Pias3 antibody, pias3.L antibody
- Background
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PIAS3 is a member of the protein inhibitor of activated STAT (PIAS) family. It also activates TGF-beta/SMAD transcriptional responses. This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: FLJ14651, ZMIZ5
Protein Interaction Partner: UBC, HIC1, TRIM63, TRIM55, TAB2, SUMO1, CBS, SUMO2, SUMO3, STAT3, NCOA2, CREM, PRPF40A, SERPINA10, GEMIN4, UBE2I, SKIL, HNRNPK, ZFHX3, SERBP1, SATB1, ERBB4, Bcl11a, ELAVL1, PPP1CA, Grm7, Grm8, Grm6, Grm4, TRIM8, RAC1, C19orf60, CARHSP1, UBA1, PSMC1, TRIM2
Protein Size: 628 - Molecular Weight
- 68 kDa
- Gene ID
- 10401
- NCBI Accession
- NM_006099, NP_006090
- UniProt
- Q9Y6X2
- Pathways
- JAK-STAT Signaling
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