HSP70 1A antibody (Middle Region)

Catalog No. ABIN2777745

Product Details anti-HSP70 1A Antibody

Target: HSP70 1A (HSPA1A) (Heat Shock 70kDa Protein 1A (HSPA1A))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Sheep, Rabbit, Guinea Pig, Goat, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSP70 1A antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SLFEGIDFYT SITRARFEEL CSDLFRSTLE PVEKALRDAK LDKAQIHDLV

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%

Characteristics: This is a rabbit polyclonal antibody against HSPA1A. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human HSPA1A

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 476 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-HSP70 1A antibody (ABIN2777745)

Narjoz, Marisa, Imbeaud, Paris, Delacroix, Beaune, De Waziers: "Genomic consequences of cytochrome P450 2C9 overexpression in human hepatoma cells." in: Chemical research in toxicology, Vol. 22, Issue 5, pp. 779-87, (2009) (PubMed).

Target Details for HSP70 1A

Target: HSP70 1A (HSPA1A) (Heat Shock 70kDa Protein 1A (HSPA1A))

Alternative Name: HSPA1A (HSPA1A Products)

Synonyms: hsp70-4 antibody, hspa1a antibody, Hsp70-3 antibody, Hsp70.3 antibody, Hsp72 antibody, hsp68 antibody, hsp70A1 antibody, HSP72 antibody, Hsp70-1 antibody, Hspa1 antibody, Hspa1b antibody, hsp70-1 antibody, hsp70-1a antibody, hsp70i antibody, hsp72 antibody, hspa1 antibody, hspa1b antibody, HSP70-1 antibody, HSP70-1A antibody, HSP70I antibody, HSPA1 antibody, HSPA1A antibody, HSPA1B antibody, HSP70-2 antibody, HSPA2 antibody, HSP70 antibody, hspA1A antibody, heat shock cognate 70-kd protein, tandem duplicate 3 antibody, heat shock 70 kDa protein 1 antibody, heat shock 70 kDa protein II antibody, heat shock protein 1A antibody, heat shock 70kD protein 1A antibody, heat shock protein family A (Hsp70) member 1A S homeolog antibody, heat shock protein family A (Hsp70) member 1A antibody, heat shock protein 70.2 antibody, heat shock 70kDa protein 1A antibody, heat shock 70 kDa protein 1B antibody, heat shock protein 70.1 antibody, hsp70.3 antibody, LOC100023597 antibody, LOC100554002 antibody, LOC100608888 antibody, Hspa1a antibody, hspa1a.S antibody, HSPA1A antibody, HSP70.2 antibody, LOC100354037 antibody, HSP70.1 antibody

Background: HSPA1A is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1.
Alias Symbols: HSP72, HSPA1, HSP70I, HSPA1B, HSP70-1, HSP70-1A
Protein Interaction Partner: UBC, TP53, NEDD1, HAUS1, CEP76, CEP72, HAUS2, AIRE, CEP250, TUBGCP2, TUBGCP3, SAE1, CEP57, AURKB, TUBG1, AURKA, SUMO2, TUBGCP4, PPP2R1A, LGALS3BP, EMD, CDKN1A, CDC20, SUMO3, STAU1, MDM2, TRIM25, ASB10, ASB16, WWOX, EZH2, BMI1, SUZ12, TUBA4A, EIF6, ALDOC,
Protein Size: 476

Molecular Weight: 52 kDa

Gene ID: 3303

NCBI Accession: NM_005345

UniProt: P08107

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process