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NR1H2 antibody (Middle Region)

NR1H2 Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Cow, Horse, Rabbit WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2777961
  • Target See all NR1H2 Antibodies
    NR1H2 (Nuclear Receptor Subfamily 1, Group H, Member 2 (NR1H2))
    Binding Specificity
    • 15
    • 11
    • 8
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 33
    • 24
    • 9
    • 6
    • 6
    • 5
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    Human, Mouse, Rat, Dog, Guinea Pig, Cow, Horse, Rabbit
    Host
    • 45
    • 3
    • 1
    Rabbit
    Clonality
    • 46
    • 3
    Polyclonal
    Conjugate
    • 26
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NR1H2 antibody is un-conjugated
    Application
    • 42
    • 19
    • 13
    • 13
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    ETECITFLKD FTYSKDDFHR AGLQVEFINP IFEFSRAMRR LGLDDAEYAL
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
    Characteristics
    This is a rabbit polyclonal antibody against NR1H2. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human NR1H2
    Top Product
    Discover our top product NR1H2 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 461 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Fu, Mukhamedova, Ip, DSouza, Henley, DiTommaso, Kesani, Ditiatkovski, Jones, Lane, Jennings, Smyth, Kile, Sviridov: "ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis." in: Cell metabolism, Vol. 18, Issue 2, pp. 225-38, (2013) (PubMed).

  • Target
    NR1H2 (Nuclear Receptor Subfamily 1, Group H, Member 2 (NR1H2))
    Alternative Name
    NR1H2 (NR1H2 Products)
    Synonyms
    NR1H2 antibody, lxr-b antibody, lxrb antibody, ner antibody, ner-i antibody, rip15 antibody, unr antibody, DKFZp468A0622 antibody, AI194859 antibody, LXR antibody, LXRB antibody, LXRbeta antibody, NER1 antibody, OR-1 antibody, RIP15 antibody, UR antibody, Unr antibody, Unr2 antibody, LXR-b antibody, NER antibody, NER-I antibody, UNR antibody, nuclear receptor subfamily 1 group H member 2 antibody, nuclear receptor subfamily 1, group H, member 2 antibody, nuclear receptor subfamily 1 group H member 2 L homeolog antibody, NR1H2 antibody, nr1h2 antibody, Nr1h2 antibody, nr1h2.L antibody
    Background
    NR1H2 is an orphan receptor. NR1H2 binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4).The LX receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize with retinoid X receptor (see MIM 180245) and bind to specific response elements (LXREs) characterized by direct repeats separated by 4 nucleotides. Two genes, alpha (LXRA, MIM 602423) and beta, are known to encode LXR proteins (Song et al., 1995 [PubMed 7625741]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: LXR-b, LXRB, NER, NER-I, RIP15, UNR
    Protein Interaction Partner: RXRG, MDFI, KDM1A, SUV39H1, ACVRL1, LAMC3, NCOR2, YY1, NPY, CDKN1A, PPARGC1B, PDCD4, PIAS1, USP7, PRKCA, SENP3, CORO2A, MPP1, COL4A5, CHD3, RMI1, CSAD, DUSP12, C14orf1, FAF1, SPRY2, HMGXB4, SORBS2, BAG6, VIM, UBE2D1, SMPD1, ROBO2, NCOR1, NRIP1, NCOA3, VDR
    Protein Size: 461
    Molecular Weight
    51 kDa
    Gene ID
    7376
    NCBI Accession
    NM_007121, NP_009052
    UniProt
    P55055
    Pathways
    Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Nuclear Hormone Receptor Binding
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