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Claudin 5 antibody (C-Term)

CLDN5 Reactivity: Human, Rat, Mouse, Pig, Cow, Rabbit, Guinea Pig WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2778047
  • Target See all Claudin 5 (CLDN5) Antibodies
    Claudin 5 (CLDN5)
    Binding Specificity
    • 10
    • 6
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 59
    • 38
    • 35
    • 17
    • 16
    • 14
    • 2
    • 1
    • 1
    Human, Rat, Mouse, Pig, Cow, Rabbit, Guinea Pig
    Host
    • 55
    • 6
    Rabbit
    Clonality
    • 48
    • 13
    Polyclonal
    Conjugate
    • 31
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This Claudin 5 antibody is un-conjugated
    Application
    • 32
    • 20
    • 18
    • 13
    • 6
    • 6
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    GWAATALLMV GGCLLCCGAW VCTGRPDLSF PVKYSAPRRP TATGDYDKKN
    Predicted Reactivity
    Cow: 93%, Guinea Pig: 86%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 93%, Rat: 93%
    Characteristics
    This is a rabbit polyclonal antibody against CLDN5. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human CLDN5
    Isotype
    IgG
    Top Product
    Discover our top product CLDN5 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 218 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Yang, Liu, Miao, Yang, Fu, Dou, Cai, Zong, Tan, Chen, Wang: "Induction of VEGFA and Snail-1 by meningitic Escherichia coli mediates disruption of the blood-brain barrier." in: Oncotarget, Vol. 7, Issue 39, pp. 63839-63855, (2016) (PubMed).

    Fontijn, Volger, Fledderus, Reijerkerk, de Vries, Horrevoets: "SOX-18 controls endothelial-specific claudin-5 gene expression and barrier function." in: American journal of physiology. Heart and circulatory physiology, Vol. 294, Issue 2, pp. H891-900, (2008) (PubMed).

  • Target
    Claudin 5 (CLDN5)
    Alternative Name
    CLDN5 (CLDN5 Products)
    Synonyms
    AWAL antibody, BEC1 antibody, CPETRL1 antibody, TMVCF antibody, cld5 antibody, awal antibody, bec1 antibody, claudin-5 antibody, cpetrl1 antibody, tmvcf antibody, AI854493 antibody, MBEC1 antibody, Tmvcf antibody, cldn5 antibody, zgc:85723 antibody, zgc:103419 antibody, claudin 5 antibody, Claudin-5 antibody, claudin 5 (transmembrane protein deleted in velocardiofacial syndrome) antibody, claudin 5a antibody, claudin 5b antibody, claudin 5 (transmembrane protein deleted in velocardiofacial syndrome) L homeolog antibody, CLDN5 antibody, cld5 antibody, cldn5 antibody, Cldn5 antibody, cldn5a antibody, cldn5b antibody, cldn5.L antibody
    Background
    CLDN5 is a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome.This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: AWAL, BEC1, CPETRL1, TMVCF
    Protein Interaction Partner: UBC, MPDZ, CLDN3, CLDN5, TJP1, CLDN1,
    Protein Size: 218
    Molecular Weight
    23 kDa
    Gene ID
    7122
    NCBI Accession
    NM_003277, NP_003268
    UniProt
    O00501
    Pathways
    Hepatitis C
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