NR1H4 antibody (Middle Region)

Catalog No. ABIN2778066

Product Details anti-NR1H4 Antibody

Target: NR1H4 (Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4))

Binding Specificity: Middle Region

Reactivity: Human, Rat, Mouse, Dog, Horse, Cow, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NR1H4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: AECLLTEIQC KSKRLRKNVK QHADQTVNED SEGRDLRQVT STTKSCREKT

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against NR1H4. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human NR1H4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 472 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for NR1H4

Target: NR1H4 (Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4))

Alternative Name: NR1H4 (NR1H4 Products)

Background: The NR1H4 gene encodes a protein that has a central role in lipid homeostasis and also regulates carbohydrate metabolism.
Alias Symbols: BAR, FXR, HRR-1, HRR1, MGC163445, RIP14
Protein Interaction Partner: SMARCD3, HDAC6, SUMO1, NCOR2, ESR1, RRM2, GPS2, RXRG, GAPDH, RXRA, EP300, SIRT1, SRC, NCOA6, CARM1, HIST1H4A, HIST1H3A, PRMT1, NCOR1, XRCC5, PRKDC, XRCC6, NCOA1, CASP8, SMARCD1,
Protein Size: 472

Molecular Weight: 54 kDa

Gene ID: 9971

NCBI Accession: NM_005123, NP_005114

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Carbohydrate Metabolic Process