Poly (ADP-Ribose) Polymerase Family, Member 16 (PARP16) (N-Term) antibody

Details for Product No. ABIN2778106, Supplier: Log in to see
Antigen
  • PARP16
  • zgc:77744
  • ARTD15
  • C15orf30
  • pART15
  • BC055447
  • C79952
  • PARP-16
  • LRRGT00109
  • RGD1306243
  • poly (ADP-ribose) polymerase family, member 16
  • PARP16
  • parp16
  • LOC100356219
  • Parp16
Epitope
N-Term
11
10
8
1
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus)
49
18
18
3
3
2
2
2
2
1
Host
Rabbit
42
7
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
30
23
17
16
13
7
Options
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Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human PARP16
Blocking Peptide Blocking peptide for this product available: ABIN981362
Sequence KRDSVLRPFP ASYARGDCKD FEALLADASK LPNLKELLQS SGDNHKRAWD
Predicted Reactivity Cow: 100%, Dog: 93%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%
Characteristics This is a rabbit polyclonal antibody against PARP16. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name PARP16
Background Poly(ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. PARP16 is a member of poly(ADP-ribose) polymerases (PARPs) family that is encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding novel PARPs now extends considerably the field of poly(ADP-ribosyl)ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post-translational modification of proteins.
Alias Symbols: pART15, C15orf30
Protein Interaction Partner: GMCL1, UBC, NEDD4,
Protein Size: 323
Molecular Weight 36 kDa
Gene ID 54956
NCBI Accession NM_017851, NP_060321
UniProt Q6PK64
Research Area Chromatin and Nuclear Signaling
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 323 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Supplier Images
Western Blotting (WB) image for anti-Poly (ADP-Ribose) Polymerase Family, Member 16 (PARP16) (N-Term) antibody (ABIN2778106) anti-Poly (ADP-Ribose) Polymerase Family, Member 16 (PARP16) (N-Term) antibody
Background publications Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

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