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ATP7A antibody (N-Term)

ATP7A Reactivity: Human, Rat, Mouse, Dog, Cow, Horse, Sheep, Pig WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2778125
  • Target See all ATP7A Antibodies
    ATP7A (ATPase, Cu++ Transporting, alpha Polypeptide (ATP7A))
    Binding Specificity
    • 15
    • 15
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 50
    • 28
    • 27
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Rat, Mouse, Dog, Cow, Horse, Sheep, Pig
    Host
    • 35
    • 15
    • 1
    • 1
    Rabbit
    Clonality
    • 37
    • 15
    Polyclonal
    Conjugate
    • 24
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ATP7A antibody is un-conjugated
    Application
    • 42
    • 20
    • 15
    • 14
    • 13
    • 13
    • 13
    • 12
    • 7
    • 4
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    MKKQIEAMGF PAFVKKQPKY LKLGAIDVER LKNTPVKSSE GSQQRSPSYQ
    Specificity
    The immunizing peptide used to raise this antibody is 100 % homologous to isoform 3 (503aa 54.3 kDa), 1 (1514aa, 165 kDa), 2 (1581aa, 172 kDa) and 5 (1422aa, 154 kDa) of human ATP7A.
    Predicted Reactivity
    Cow: 93%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%, Sheep: 100%
    Characteristics
    This is a rabbit polyclonal antibody against ATP7A. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Protein A purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human ATP7A
    Top Product
    Discover our top product ATP7A Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 1500 AAAA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    ATP7A (ATPase, Cu++ Transporting, alpha Polypeptide (ATP7A))
    Alternative Name
    ATP7A (ATP7A Products)
    Synonyms
    ATP7A antibody, cal antibody, wu:fc43e01 antibody, zgc:153422 antibody, zgc:158633 antibody, DDBDRAFT_0218568 antibody, DDBDRAFT_0235190 antibody, DDB_0218568 antibody, DDB_0235190 antibody, atpase antibody, Atp7a antibody, kal antibody, atp7a antibody, DSMAX antibody, MK antibody, MNK antibody, SMAX3 antibody, Blo antibody, DXHXS1608e antibody, I14 antibody, Mo antibody, blotchy antibody, br antibody, brindled antibody, mottled antibody, Mnk antibody, ATPase copper transporting alpha antibody, ATPase, Cu++ transporting, alpha polypeptide antibody, P-type ATPase antibody, ATP synthase subunit a antibody, copper-transporting ATPase 1 antibody, ATP7A antibody, atp7a antibody, LOC100049514 antibody, Atp7a antibody, LOC412379 antibody
    Background
    The ATP7A gene encodes the Menkes copper-translocating P-type ATPase, a ubiquitous protein that regulates the absorption of copper in the gastrointestinal tract. Inside cells, this protein has a dual function: it delivers copper to cuproenzymes in the Golgi compartment and effluxes excess copper. The trafficking mechanism and catalytic activity combine to facilitate absorption and intercellular transport of copper. Menkes disease, a systemic copper deficiency disorder, is caused by mutations in the ATP7A gene.
    Alias Symbols: MK, MNK, DSMAX, SMAX3
    Protein Interaction Partner: ACIN1, UBC, COMMD1, CLU, ATOX1, PDZD11, CP, GLRX,
    Protein Size: 1500aa
    Molecular Weight
    163 kDa
    Gene ID
    538
    NCBI Accession
    NM_000052, NP_000043
    UniProt
    Q04656
    Pathways
    Transition Metal Ion Homeostasis, Ribonucleoside Biosynthetic Process
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