ATP7A antibody (N-Term)
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- Target See all ATP7A Antibodies
- ATP7A (ATPase, Cu++ Transporting, alpha Polypeptide (ATP7A))
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Binding Specificity
- N-Term
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Reactivity
- Human, Rat, Mouse, Dog, Cow, Horse, Sheep, Pig
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ATP7A antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- MKKQIEAMGF PAFVKKQPKY LKLGAIDVER LKNTPVKSSE GSQQRSPSYQ
- Specificity
- The immunizing peptide used to raise this antibody is 100 % homologous to isoform 3 (503aa 54.3 kDa), 1 (1514aa, 165 kDa), 2 (1581aa, 172 kDa) and 5 (1422aa, 154 kDa) of human ATP7A.
- Predicted Reactivity
- Cow: 93%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%, Sheep: 100%
- Characteristics
- This is a rabbit polyclonal antibody against ATP7A. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Protein A purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human ATP7A
- Top Product
- Discover our top product ATP7A Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 1500 AAAA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- ATP7A (ATPase, Cu++ Transporting, alpha Polypeptide (ATP7A))
- Alternative Name
- ATP7A (ATP7A Products)
- Synonyms
- ATP7A antibody, cal antibody, wu:fc43e01 antibody, zgc:153422 antibody, zgc:158633 antibody, DDBDRAFT_0218568 antibody, DDBDRAFT_0235190 antibody, DDB_0218568 antibody, DDB_0235190 antibody, atpase antibody, Atp7a antibody, kal antibody, atp7a antibody, DSMAX antibody, MK antibody, MNK antibody, SMAX3 antibody, Blo antibody, DXHXS1608e antibody, I14 antibody, Mo antibody, blotchy antibody, br antibody, brindled antibody, mottled antibody, Mnk antibody, ATPase copper transporting alpha antibody, ATPase, Cu++ transporting, alpha polypeptide antibody, P-type ATPase antibody, ATP synthase subunit a antibody, copper-transporting ATPase 1 antibody, ATP7A antibody, atp7a antibody, LOC100049514 antibody, Atp7a antibody, LOC412379 antibody
- Background
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The ATP7A gene encodes the Menkes copper-translocating P-type ATPase, a ubiquitous protein that regulates the absorption of copper in the gastrointestinal tract. Inside cells, this protein has a dual function: it delivers copper to cuproenzymes in the Golgi compartment and effluxes excess copper. The trafficking mechanism and catalytic activity combine to facilitate absorption and intercellular transport of copper. Menkes disease, a systemic copper deficiency disorder, is caused by mutations in the ATP7A gene.
Alias Symbols: MK, MNK, DSMAX, SMAX3
Protein Interaction Partner: ACIN1, UBC, COMMD1, CLU, ATOX1, PDZD11, CP, GLRX,
Protein Size: 1500aa - Molecular Weight
- 163 kDa
- Gene ID
- 538
- NCBI Accession
- NM_000052, NP_000043
- UniProt
- Q04656
- Pathways
- Transition Metal Ion Homeostasis, Ribonucleoside Biosynthetic Process
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