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XRCC5 antibody (C-Term)

XRCC5 Reactivity: Human, Mouse, Rat, Dog, Horse, Rabbit, Cow, Guinea Pig WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2778271
  • Target See all XRCC5 Antibodies
    XRCC5 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5))
    Binding Specificity
    • 15
    • 13
    • 8
    • 7
    • 6
    • 6
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    Human, Mouse, Rat, Dog, Horse, Rabbit, Cow, Guinea Pig
    Host
    • 77
    • 14
    • 2
    • 1
    Rabbit
    Clonality
    • 69
    • 23
    Polyclonal
    Conjugate
    • 64
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This XRCC5 antibody is un-conjugated
    Application
    • 80
    • 41
    • 38
    • 30
    • 20
    • 12
    • 12
    • 10
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    GITLITKEEA SGSSVTAEEA KKFLAPKDKP SGDTAAVFEE GGDVDDLLDM
    Predicted Reactivity
    Cow: 92%, Dog: 92%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 85%, Rabbit: 93%, Rat: 100%
    Characteristics
    This is a rabbit polyclonal antibody against XRCC5. It was validated on Western Blot and immunohistochemistry.
    Purification
    Protein A purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human XRCC5
    Top Product
    Discover our top product XRCC5 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 732 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    XRCC5 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5))
    Alternative Name
    XRCC5 (XRCC5 Products)
    Synonyms
    AI314015 antibody, Ku80 antibody, Ku86 antibody, Kup80 antibody, KARP-1 antibody, KARP1 antibody, KU80 antibody, KUB2 antibody, NFIV antibody, xrcc5-a antibody, XRCC5 antibody, X-ray repair cross complementing 5 antibody, X-ray repair complementing defective repair in Chinese hamster cells 5 antibody, X-ray repair complementing defective repair in Chinese hamster cells 5 L homeolog antibody, XRCC5 antibody, Xrcc5 antibody, xrcc5.L antibody
    Background
    XRCC5 encodes the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
    Alias Symbols: KU80, KUB2, Ku86, NFIV, KARP1, KARP-1
    Protein Interaction Partner: HUWE1, UBC, EHF, ELF3, SUMO2, SUMO3, BRCA1, ATRX, Fbxl16, NEDD8, SUMO1, MDM2, RPA3, RPA2, RPA1, SUZ12, EED, RNF2, BMI1, EIF4B, C1QBP, RPL24, PLCB3, PRMT3, EIF3J, CUL2, CSDE1, SF1, TRMT1, SAMHD1, DNMBP, GANAB, HYOU1, NCL, NARS, MSH2, JUP, HSPA4, PARP1, TAR
    Protein Size: 732
    Molecular Weight
    83 kDa
    Gene ID
    7520
    NCBI Accession
    NM_021141, NP_066964
    UniProt
    Q4VBQ5
    Pathways
    DNA Damage Repair
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