PER1 antibody (N-Term)

Catalog No. ABIN2778294

Product Details anti-PER1 Antibody

Target: PER1 (Period Homolog 1 (Drosophila) (PER1))

Binding Specificity: N-Term

Reactivity: Human, Rat, Mouse, Horse, Guinea Pig, Cow, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PER1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: ESFCPGGVPS PGPPQHRPCP GPSLADDTDA NSNGSSGNES NGHESRGASQ

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PER1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of human PER1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PER1

Target: PER1 (Period Homolog 1 (Drosophila) (PER1))

Alternative Name: PER1 (PER1 Products)

Synonyms: PER antibody, RIGUI antibody, hPER antibody, per1 antibody, si:ch211-237l4.4 antibody, Per antibody, m-rigui antibody, mPer1 antibody, rper1 antibody, Rigui-like antibody, per4 antibody, zfper4 antibody, period circadian regulator 1 antibody, period circadian clock 1a antibody, period circadian clock 1 antibody, period homolog 1 (Drosophila) antibody, period circadian clock 1b antibody, PER1 antibody, per1a antibody, per1 antibody, Per1 antibody, per1b antibody

Background: This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. Alternative splicing has been observed in this gene, however, these variants have not been fully described.
Alias Symbols: PER, hPER, RIGUI
Protein Size: 294

Molecular Weight: 32 kDa

Gene ID: 5187

NCBI Accession: NM_002616, NP_002607

UniProt: O15534

Pathways: Photoperiodism