PSMC2 antibody (N-Term)

Catalog No. ABIN2778346

Product Details anti-PSMC2 Antibody

Target: PSMC2 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2 (PSMC2))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Dog, Rabbit, Cow, Guinea Pig, Horse, Goat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMC2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MPDYLGADQR KTKEDEKDDK PIRALDEGDI ALLKTYGQST YSRQIKQVED

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 77%, Guinea Pig: 100%, Horse: 92%, Human: 100%, Mouse: 92%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PSMC2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PSMC2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 433 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PSMC2

Target: PSMC2 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2 (PSMC2))

Alternative Name: PSMC2 (PSMC2 Products)

Synonyms: xMSS1 antibody, psmc2 antibody, DDBDRAFT_0168337 antibody, DDBDRAFT_0232966 antibody, DDB_0168337 antibody, DDB_0232966 antibody, MSS1 antibody, Nbla10058 antibody, S7 antibody, NCU02840.1 antibody, zgc:63995 antibody, proteasome 26S subunit, ATPase 2 L homeolog antibody, proteasome (prosome, macropain) 26S subunit, ATPase 2 antibody, 26S protease regulatory subunit 7 antibody, proteasome 26S subunit, ATPase 2 antibody, regulatory particle, ATPase-like-1 antibody, psmc2.L antibody, psmc2 antibody, psmC2 antibody, PSMC2 antibody, rpt-1 antibody, GL50803_21331 antibody, EHI_080890 antibody, UREG_01412 antibody, PITG_10169 antibody, Psmc2 antibody, GL50803_86683 antibody, Tsp_09237 antibody

Background: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. In case of HIV-1 infection, PSMC2 is a positive modulator of Tat-mediated transactivation.The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MGC3004, MSS1, Nbla10058, S7
Protein Interaction Partner: HUWE1, UBC, PSMD5, SPRTN, SUMO2, SHFM1, PSMD14, PSMD4, RNF2, PSMC1, CLIP1, RPS21, PSMD12, PSMD11, PSMD8, PSMD3, PSMD2, PSMD1, PSMC6, PSMC3, ADRM1, TXNL1, FBXO6, PARK2, BAG3, NOS2, SKIL, RAD23A, PCDH10, UCHL5, PSMD6, PSMD13, PSMD7, PSMC4, ZCCHC8, UFC1, MRP
Protein Size: 433

Molecular Weight: 49 kDa

Gene ID: 5701

NCBI Accession: NM_002803, NP_002794

UniProt: P35998

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway