EYA4 antibody (N-Term)

Catalog No. ABIN2778551

Product Details anti-EYA4 Antibody

Target: EYA4 (Eyes Absent Homolog 4 (EYA4))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rabbit, Guinea Pig, Dog, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EYA4 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MEDTQDLNEQ SVKKTCPEAD VSEPQNSRSM EMQDLASPHA LVGGSDTPGS

Predicted Reactivity: Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Zebrafish: 85%

Characteristics: This is a rabbit polyclonal antibody against Eya4. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Eya4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 616 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for EYA4

Target: EYA4 (Eyes Absent Homolog 4 (EYA4))

Alternative Name: Eya4 (EYA4 Products)

Synonyms: B130023L16Rik antibody, CMD1J antibody, DFNA10 antibody, EYA transcriptional coactivator and phosphatase 4 antibody, Eya4 antibody, EYA4 antibody

Background: Eya4 is a tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Eya4 promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. It may be involved in development of the eye.
Alias Symbols: B130023L16Rik
Protein Interaction Partner: Six1, Six2, Eya4,
Protein Size: 616

Molecular Weight: 67 kDa

Gene ID: 14051

NCBI Accession: NM_010167, NP_034297

UniProt: Q9Z191

Pathways: Sensory Perception of Sound