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PCBP1 antibody (Middle Region)

PCBP1 Reactivity: Human, Mouse, Rat, Cow, Rabbit, Dog, Horse, Guinea Pig WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2778970
  • Target See all PCBP1 Antibodies
    PCBP1 (Poly(rC) Binding Protein 1 (PCBP1))
    Binding Specificity
    • 7
    • 6
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 42
    • 14
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat, Cow, Rabbit, Dog, Horse, Guinea Pig
    Host
    • 34
    • 6
    • 2
    Rabbit
    Clonality
    • 36
    • 6
    Polyclonal
    Conjugate
    • 21
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PCBP1 antibody is un-conjugated
    Application
    • 30
    • 22
    • 7
    • 3
    • 3
    • 1
    Western Blotting (WB)
    Sequence
    CSDAVGYPHA THDLEGPPLD AYSIQGQHTI SPLDLAKLNQ VARQQSHFAM
    Predicted Reactivity
    Cow: 93%, Dog: 92%, Guinea Pig: 93%, Horse: 93%, Human: 93%, Mouse: 93%, Rabbit: 93%, Rat: 93%
    Characteristics
    This is a rabbit polyclonal antibody against PCBP1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Protein A purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human PCBP1
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    Discover our top product PCBP1 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 356 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    PCBP1 (Poly(rC) Binding Protein 1 (PCBP1))
    Alternative Name
    PCBP1 (PCBP1 Products)
    Synonyms
    PCBP1 antibody, HNRPE1 antibody, HNRPX antibody, hnRNP-E1 antibody, hnRNP-X antibody, hnRNP E1 antibody, WBP17 antibody, [a]CP-1 antibody, alphaCP-1 antibody, RGD1561319 antibody, poly(rC) binding protein 1 antibody, poly(rC) binding protein 1 L homeolog antibody, poly(rC)-binding protein 1 antibody, PCBP1 antibody, pcbp1.L antibody, LOC100388387 antibody, Pcbp1 antibody
    Background
    PCBP1 appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. PCBP1 is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.This intronless gene is thought to be generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding proteins. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.
    Alias Symbols: HNRPX, HNRPE1, hnRNP-X, hnRNP-E1
    Protein Interaction Partner: HUWE1, UBC, SNRPA, TP53, SUMO2, SUMO3, TUBGCP3, STAU1, ERG, EED, TUBB6, TUBB2A, PFKP, PFKM, SRPK2, SRPK1, SRPK3, FBXO6, TARDBP, UBD, ADRB2, NPM1, LMNA, HMGA1, CD81, PAN2, PRPF8, PPIG, PRPF3, UBL4A, ANP32A, VCAM1, NOS2, ITGA4, FN1, ATF2, ZNF830, ZCCHC10, P
    Protein Size: 356
    Molecular Weight
    39 kDa
    Gene ID
    5093
    NCBI Accession
    NM_006196, NP_006187
    UniProt
    Q15365
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