CDKN2AIP antibody (C-Term)

Catalog No. ABIN2779115

Product Details anti-CDKN2AIP Antibody

Target: CDKN2AIP (CDKN2A Interacting Protein (CDKN2AIP))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Dog, Rabbit, Cow, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDKN2AIP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: AIEALKATLD VFFVPLKELA DLPQNKSSQE SIVCELRCKS VYLGTGCGKS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against CARF. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CARF

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 580 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CDKN2AIP

Target: CDKN2AIP (CDKN2A Interacting Protein (CDKN2AIP))

Alternative Name: CARF (CDKN2AIP Products)

Synonyms: CARF antibody, 4921511I16Rik antibody, AW208986 antibody, CDKN2AIP antibody, RGD1305302 antibody, CDKN2A interacting protein antibody, CDKN2A interacting protein L homeolog antibody, CDKN2AIP antibody, Cdkn2aip antibody, cdkn2aip antibody, cdkn2aip.L antibody

Background: CARF was first cloned as a novel binding partner of ARF from a yeast-interactive screen. CARF and ARF colocalize in the perinucleolar region and have a collaborative function. In the nucleoplasm, CARF interacts with p53 and enhances its function. The p53 downregulates CARF in a negative feedback regulatory loop and may also involve p53 antagonist HDM2.
Alias Symbols: CARF
Protein Interaction Partner: UBC, XRN2, RPA3, RPA2, RPA1, WHSC1, VCP, Cdkn2a, MDC1, BRCA1, BARD1, GGH, EPHX1, MDM2, CUL3, SUMO2, RAD21, DHX58, Clp1,
Protein Size: 580

Molecular Weight: 64 kDa

Gene ID: 55602

NCBI Accession: NM_017632, NP_060102

UniProt: Q9NXV6