MATR3 antibody (N-Term)

Catalog No. ABIN2779141

Product Details anti-MATR3 Antibody

Target: MATR3 (Matrin 3 (MATR3))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MATR3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: MSKSFQQSSL SRDSQGHGRD LSAAGIGLLA AATQSLSMPA SLGRMNQGTA

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against MATR3. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MATR3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 847 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-MATR3 antibody (ABIN2779141)

Kula, Gharu, Marcello: "HIV-1 pre-mRNA commitment to Rev mediated export through PSF and Matrin 3." in: Virology, Vol. 435, Issue 2, pp. 329-40, (2012) (PubMed).

Kula, Guerra, Knezevich, Kleva, Myers, Marcello: "Characterization of the HIV-1 RNA associated proteome identifies Matrin 3 as a nuclear cofactor of Rev function." in: Retrovirology, Vol. 8, pp. 60, (2011) (PubMed).

Valencia, Ju, Liu: "Matrin 3 is a Ca2+/calmodulin-binding protein cleaved by caspases." in: Biochemical and biophysical research communications, Vol. 361, Issue 2, pp. 281-6, (2007) (PubMed).

Target Details for MATR3

Target: MATR3 (Matrin 3 (MATR3))

Alternative Name: MATR3 (MATR3 Products)

Background: MATR3 is localized in the nuclear matrix. It may play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network.The protein encoded by this gene is localized in the nuclear matrix. It may play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. Two transcript variants encoding the same protein have been identified for this gene.
Alias Symbols: MPD2, VCPDM
Protein Interaction Partner: RASD1, MATR3, UBC, HNRNPK, CEP250, AURKA, SUMO2, SUMO3, STAU1, LGR4, SUMO1, MDM2, RPA3, RPA2, RPA1, ERG, WWOX, EED, rev, PARK2, TARDBP, PAN2, ITGA4, IFIT2, FN1, MAP1LC3A, PTBP2, vpr, MAGOH, EIF4A3, PRKCDBP, NAA15, IARS2, SMU1, SARS2, STOML2, RRP7A, MYOF,
Protein Size: 847

Molecular Weight: 93 kDa

Gene ID: 9782

NCBI Accession: NM_018834, NP_061322

UniProt: P43243