beta Arrestin 1 antibody (Middle Region)
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- Target See all beta Arrestin 1 (ARRB1) Antibodies
- beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))
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Binding Specificity
- Middle Region
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Reactivity
- Human, Cow, Horse, Dog
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This beta Arrestin 1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- NETPVDTNLI ELDTNDDDIV FEDFARQRLK GMKDDKEEEE DGTGSPQLNN
- Predicted Reactivity
- Cow: 90%, Dog: 100%, Horse: 100%, Human: 100%
- Characteristics
- This is a rabbit polyclonal antibody against ARRB1. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human ARRB1
- Top Product
- Discover our top product ARRB1 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 418 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))
- Alternative Name
- ARRB1 (ARRB1 Products)
- Synonyms
- arrb1 antibody, MGC83787 antibody, arb1 antibody, arr1 antibody, barr1 antibody, betaarr1 antibody, 1200006I17Rik antibody, AW208571 antibody, G430100A01Rik antibody, ARB1 antibody, ARR1 antibody, BARRES antibody, arrestin beta 1 antibody, arrestin, beta 1 antibody, arrestin beta 1 L homeolog antibody, beta-arrestin 1 antibody, putative beta-arrestin 1 antibody, ARRB1 antibody, arrb1 antibody, arrb1.L antibody, CpipJ_CPIJ016988 antibody, CpipJ_CPIJ017114 antibody, Smp_122900 antibody, Smp_126080 antibody, Smp_176980 antibody, Smp_152290 antibody, Arrb1 antibody
- Background
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Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known.
Alias Symbols: ARB1, ARR1
Protein Interaction Partner: MAPK9, UBC, PTGER4, SRC, GNMT, NOTCH1, ARRDC1, PTAFR, MAP2K3, LIMK1, PDXP, MAPK14, CLTC, CFL1, AP2A1, MAP3K5, AKT1, AGTR1, MAP2K4, MAPK10, CSK, EDNRA, Agtr1a, NEK6, PIK3R2, NFKBIA, AXIN1, YY1, BTK, BAG1, ADRB1, ADH6, RPL15, PDE4D, Mlnr, Trhr, ARRDC4, ARRD
Protein Size: 418 - Molecular Weight
- 47 kDa
- Gene ID
- 408
- NCBI Accession
- NM_004041, NP_004032
- UniProt
- P49407
- Pathways
- Positive Regulation of Peptide Hormone Secretion, Nuclear Hormone Receptor Binding, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
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