IRF5 antibody (Middle Region)

Catalog No. ABIN2779405

Product Details anti-IRF5 Antibody

Target: IRF5 (Interferon Regulatory Factor 5 (IRF5))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Pig, Horse, Dog, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRF5 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: IFFCFGEEWP DRKPREKKLI TVQVVPVAAR LLLEMFSGEL SWSADSIRLQ

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%

Characteristics: This is a rabbit polyclonal antibody against IRF5. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human IRF5

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 498 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-IRF5 antibody (ABIN2779405)

Coletta, Cullington, Clark, Cleland: "Clinical trials update from European Society of Cardiology meeting 2008: TIME-CHF, BACH, BEAUTIFUL, GISSI-HF, and HOME-HF." in: European journal of heart failure, Vol. 10, Issue 12, pp. 1264-7, (2008) (PubMed).

Target Details for IRF5

Target: IRF5 (Interferon Regulatory Factor 5 (IRF5))

Alternative Name: IRF5 (IRF5 Products)

Synonyms: IRF5 antibody, irf5 antibody, SLEB10 antibody, AW491843 antibody, mirf5 antibody, im:7155364 antibody, zgc:76986 antibody, interferon regulatory factor 5 antibody, interferon regulatory factor 5 L homeolog antibody, IRF5 antibody, irf5 antibody, Irf5 antibody, irf5.L antibody

Background: IRF5 is a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative splice variants encoding different isoforms exist. This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative splice variants encoding different isoforms exist.
Alias Symbols: SLEB10
Protein Interaction Partner: SGTA, IRF5, COPS7B, COPS4, COPS5, COPS6, COPS8, COPS2, COPS3, UBC, GPS1, TRAF6, MYD88, RGS3, PPM1G, IRF6, HIVEP1, GRB2, CHUK, ALPI, MAVS, GTPBP2, CEP152, GTPBP1, SIN3A, NCOR2, NCOR1, KAT2B, HDAC1, EP300, CREBBP, TRIM15, IKBKE, TBK1, IRF3, XPO1,
Protein Size: 498

Molecular Weight: 56 kDa

Gene ID: 3663

NCBI Accession: NM_032643, NP_116032

UniProt: Q13568

Pathways: TLR Signaling, Autophagy