PAX4 antibody (Middle Region)

Catalog No. ABIN2779444

Product Details anti-PAX4 Antibody

Target: PAX4 (Paired Box 4 (PAX4))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Cow, Rabbit, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAX4 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: RTIFSPSQAE ALEKEFQRGQ YPDSVARGKL ATATSLPEDT VRVWFSNRRA

Specificity: 100 % homologous to all 3 isoforms (38, 30, 37 kDa).

Predicted Reactivity: Cow: 92%, Dog: 92%, Guinea Pig: 92%, Horse: 92%, Human: 100%, Mouse: 92%, Rabbit: 92%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against PAX4. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PAX4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 343 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-PAX4 antibody (ABIN2779444)

Zhang, Smyrk, Oliveira, Lohse, Zhang, Johnson, Lloyd: "KIT is an independent prognostic marker for pancreatic endocrine tumors: a finding derived from analysis of islet cell differentiation markers." in: The American journal of surgical pathology, Vol. 33, Issue 10, pp. 1562-9, (2010) (PubMed).

Target Details for PAX4

Target: PAX4 (Paired Box 4 (PAX4))

Alternative Name: PAX4 (PAX4 Products)

Synonyms: KPD antibody, MODY9 antibody, Pax-4 antibody, PAX4 antibody, paired box 4 antibody, PAX4 antibody, Pax4 antibody

Background: PAX4 is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box gene 4 is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing .- cells.
Alias Symbols: KPD, MGC129960, MODY9
Protein Interaction Partner: GMCL1,
Protein Size: 343

Molecular Weight: 37 kDa

Gene ID: 5078

NCBI Accession: NM_006193, NP_006184

UniProt: O43316