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POU1F1 antibody (Middle Region)

POU1F1 Reactivity: Human, Mouse, Rat, Dog, Cow, Goat, Horse, Rabbit, Sheep, Guinea Pig WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2779561
  • Target See all POU1F1 Antibodies
    POU1F1 (POU Class 1 Homeobox 1 (POU1F1))
    Binding Specificity
    • 2
    • 2
    • 1
    Middle Region
    Reactivity
    • 10
    • 7
    • 7
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat, Dog, Cow, Goat, Horse, Rabbit, Sheep, Guinea Pig
    Host
    • 10
    Rabbit
    Clonality
    • 10
    Polyclonal
    Conjugate
    • 10
    This POU1F1 antibody is un-conjugated
    Application
    • 8
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    KRRTTISIAA KDALERHFGE QNKPSSQEIM RMAEELNLEK EVVRVWFCNR
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 86%, Rabbit: 100%, Rat: 93%, Sheep: 100%
    Characteristics
    This is a rabbit polyclonal antibody against POU1F1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human POU1F1
    Top Product
    Discover our top product POU1F1 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 291 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    POU1F1 (POU Class 1 Homeobox 1 (POU1F1))
    Alternative Name
    POU1F1 (POU1F1 Products)
    Synonyms
    CPHD1 antibody, GHF-1 antibody, PIT1 antibody, POU1F1a antibody, Pit-1 antibody, Hmp1 antibody, Pit1 antibody, Pit1-rs1 antibody, dw antibody, dwarf antibody, GHF1 antibody, GHF1A antibody, PIT1Z antibody, PIT-1 antibody, Pit-1* antibody, pit1 antibody, pit-1 antibody, POU class 1 homeobox 1 antibody, POU domain, class 1, transcription factor 1 antibody, POU1F1 antibody, Pou1f1 antibody, pou1f1 antibody
    Background
    PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. The POU family is so named because the first 3 members identified were PIT1 and OCT1 of mammals, and Unc-86 of C. elegans. PIT1 contains 2 protein domains, termed POU-specific and POU-homeo, which are both necessary for high affinity DNA binding on genes encoding growth hormone and prolactin. PIT1 is also important for regulation of the genes encoding prolactin and thyroid-stimulating hormone beta subunit by thyrotropin-releasing hormone and cyclic AMP. This gene encodes a member of the POU family of transcription factors that regulate mammalian development. The protein regulates expression of several genes involved in pituitary development and hormone expression. Mutations in this genes result in combined pituitary hormone deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.
    Alias Symbols: GHF-1, PIT1, Pit-1, Pit-1 beta, CPHD1, POU1F1a
    Protein Interaction Partner: CEBPD, NCOR1, CREBBP, MED1, GATA2, NR1I3, NR1I2, PITX1, JUN, ETS1, NR3C1, VDR, PPARG, PPARA,
    Protein Size: 291
    Molecular Weight
    33 kDa
    Gene ID
    5449
    NCBI Accession
    NM_000306, NP_000297
    UniProt
    P28069
    Pathways
    Regulation of Carbohydrate Metabolic Process
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