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POLR2B antibody (N-Term)

POLR2B Reactivity: Human, Mouse, Rat, Dog, Cow, Rabbit, Guinea Pig, Horse, Zebrafish (Danio rerio) WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2779657
  • Target See all POLR2B Antibodies
    POLR2B (Polymerase (RNA) II (DNA Directed) Polypeptide B, 140kDa (POLR2B))
    Binding Specificity
    • 7
    • 7
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 26
    • 7
    • 7
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Human, Mouse, Rat, Dog, Cow, Rabbit, Guinea Pig, Horse, Zebrafish (Danio rerio)
    Host
    • 26
    Rabbit
    Clonality
    • 26
    Polyclonal
    Conjugate
    • 16
    • 2
    • 2
    • 2
    • 2
    • 2
    This POLR2B antibody is un-conjugated
    Application
    • 25
    • 15
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Sequence
    TYSAPLYVDI TKTVIKEGEE QLQTQHQKTF IGKIPIMLRS TYCLLNGLTD
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%
    Characteristics
    This is a rabbit polyclonal antibody against POLR2B. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Protein A purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human POLR2B
    Top Product
    Discover our top product POLR2B Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 1174 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    POLR2B (Polymerase (RNA) II (DNA Directed) Polypeptide B, 140kDa (POLR2B))
    Alternative Name
    POLR2B (POLR2B Products)
    Synonyms
    Pol2rb antibody, Rpb140 antibody, Rpb2 antibody, POL2RB antibody, RPB2 antibody, hRPB140 antibody, hsRPB2 antibody, RNA polymerase II subunit B antibody, polymerase (RNA) II (DNA directed) polypeptide B, 140kDa antibody, DNA-directed RNA polymerase II subunit RPB2 antibody, polymerase (RNA) II (DNA directed) polypeptide B antibody, polymerase (RNA) II (DNA directed) polypeptide B, 140kDa L homeolog antibody, POLR2B antibody, polr2b antibody, LOC100640211 antibody, Polr2b antibody, polr2b.L antibody, rpb-2 antibody
    Background
    POLR2B is the second largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with at least two other polymerase subunits, forms a structure within the polymerase that maintains contact in the active site of the enzyme between the DNA template and the newly synthesized RNA.
    Alias Symbols: RPB2, POL2RB, hsRPB2, hRPB140
    Protein Interaction Partner: ESR1, UBC, TCEB3, SRC, PSMB9, SUMO2, XRN2, WWOX, SUZ12, RNF2, NEDD4, ITCH, RABEP2, HECW2, FBXO6, CDK20, HDAC11, ILK, POLR2C, MED19, MED26, RECQL5, VCP, BARD1, MDC1, POLR3F, TUBB4B, TUBA4A, POLR2I, POLR2E, POLR2D, POLR2A, DCTN1, ATP6V1B2, MEN1, CDK7, CCNH,
    Protein Size: 1174
    Molecular Weight
    134 kDa
    Gene ID
    5431
    NCBI Accession
    NM_000938, NP_000929
    UniProt
    P30876
    Pathways
    Regulatory RNA Pathways, DNA Damage Repair
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