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GFI1 antibody (N-Term)

GFI1 Reactivity: Human, Rat, Mouse, Cow, Dog, Rabbit, Guinea Pig, Horse, Pig WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2779720
  • Target See all GFI1 Antibodies
    GFI1 (Growth Factor Independent 1 (GFI1))
    Binding Specificity
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 22
    • 15
    • 14
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Rat, Mouse, Cow, Dog, Rabbit, Guinea Pig, Horse, Pig
    Host
    • 17
    • 6
    Rabbit
    Clonality
    • 19
    • 4
    Polyclonal
    Conjugate
    • 16
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GFI1 antibody is un-conjugated
    Application
    • 15
    • 7
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    VPAPSRADST SNAGGAKAEP RDRLSPESQL TEAPDRASAS PDSCEGSVCE
    Predicted Reactivity
    Cow: 100%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 79%, Rat: 100%
    Characteristics
    This is a rabbit polyclonal antibody against GFI1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human GFI1
    Top Product
    Discover our top product GFI1 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 422 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    GFI1 (Growth Factor Independent 1 (GFI1))
    Alternative Name
    GFI1 (GFI1 Products)
    Synonyms
    AW495828 antibody, Gfi-1 antibody, Pal-1 antibody, Pal1 antibody, GFI1 antibody, GFI-1 antibody, GFI1A antibody, SCN2 antibody, ZNF163 antibody, growth factor independent 1 antibody, growth factor independent 1 transcriptional repressor antibody, Gfi1 antibody, GFI1 antibody
    Background
    GFI1 may be a transcription factor involved in regulating the expression of genes active in the S phase during cell cycle progression in T-cells. GFI1 may be involved in tumor progression. Defects in GFI1 are a cause of autosomal dominant severe congenital neutropenia (SCN) and dominant nonimmune chronic idiopathic neutropenia of adults (NI-CINA) This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene.
    Alias Symbols: ZNF163, SCN2, GFI-1
    Protein Interaction Partner: RELA, SPI1, CHAF1A, PICK1, PIAS2, RCOR1, KDM1A, HDAC2, PRDM5, HDAC1, EHMT2, PIAS3, RUNX1T1, ARIH2, UBC,
    Protein Size: 422
    Molecular Weight
    45 kDa
    Gene ID
    2672
    NCBI Accession
    NM_005263, NP_005254
    UniProt
    Q99684
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