MDC1 antibody (C-Term)
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- Target See all MDC1 Antibodies
- MDC1 (Mdc1 (MDC1))
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Binding Specificity
- C-Term
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Reactivity
- Human, Dog, Guinea Pig
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This MDC1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- GKEEDVVTPK PGKRKRDQAE EEPNRIPSRS LRRTKLNQES TAPKVLFTGV
- Predicted Reactivity
- Dog: 86%, Guinea Pig: 92%, Human: 100%
- Characteristics
- This is a rabbit polyclonal antibody against MDC1. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human MDC1
- Top Product
- Discover our top product MDC1 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 2089 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- MDC1 (Mdc1 (MDC1))
- Alternative Name
- MDC1 (MDC1 Products)
- Synonyms
- 6820401C03 antibody, AA413496 antibody, Nfbd1 antibody, mKIAA0170 antibody, NFBD1 antibody, mediator of DNA damage checkpoint 1 antibody, mediator of DNA-damage checkpoint 1 antibody, Mdc1 antibody, MDC1 antibody
- Background
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The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
Alias Symbols: DKFZp781A0122, KIAA0170, MGC166888, NFBD1
Protein Interaction Partner: RPA3, RPA2, RPA1, EED, TOPBP1, RNF8, UBC, LMNA, RAG1, CDC27, NCL, NBN, MRE11A, CSNK2A1, RAD50, CAPZB, CAPZA1, AUP1, ATP2A2, LOC729324, CHAMP1, HNRNPUL2, PGAM5, LSM12, ANAPC16, OSBPL8, DTX2, ZNF251, RBM17, FAM175A, LAS1L, LPCAT1, MYH14, SLC25A22, ZNF768, H
Protein Size: 2089 - Molecular Weight
- 227 kDa
- Gene ID
- 9656
- NCBI Accession
- NM_014641, NP_055456
- UniProt
- Q14676
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