NKX3-1 antibody (Middle Region)

Catalog No. ABIN2779964

Product Details anti-NKX3-1 Antibody

Target: NKX3-1 (NK3 Homeobox 1 (NKX3-1))

Binding Specificity: Middle Region

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NKX3-1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: TPTEPESDAH FETYLLDCEH NPGDLASAPQ VTKQPQKRSR AAFSHTQVIE

Predicted Reactivity: Mouse: 100%

Characteristics: This is a rabbit polyclonal antibody against Nkx3-1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Mouse Nkx3-1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 237 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for NKX3-1

Target: NKX3-1 (NK3 Homeobox 1 (NKX3-1))

Alternative Name: Nkx3-1 (NKX3-1 Products)

Synonyms: Xbagpipe antibody, Xbap antibody, bagpipe antibody, koza antibody, nkx3-1 antibody, nkx3.1 antibody, si:ch211-67o1.2 antibody, nkx3a antibody, MGC53041 antibody, MGC97890 antibody, Bax antibody, NKX3.1 antibody, NKX3A antibody, Nkx-3.1 antibody, BAPX2 antibody, NKX3 antibody, NK3 homeobox 1 L homeolog antibody, NK3 homeobox 1 antibody, NK-3 transcription factor, locus 1 (Drosophila) antibody, nkx3-1.L antibody, NKX3-1 antibody, nkx3-1 antibody, Nkx3-1 antibody

Background: Nkx3-1 is a transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. It plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Nkx3-1 acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to suppress growth and tumorigenicity of prostate carcinoma cells and plays a role in the formation of minor salivary glands (particularly palatine and lingual glands). It is essential for appropriate differentiation and secretory function of the bulbourethral gland.
Alias Symbols: Bax, NKX3.1, NKX3A, Nkx-3.1, bagpipe
Protein Interaction Partner: Fem1b, SP2,
Protein Size: 237

Molecular Weight: 27 kDa

Gene ID: 18095

NCBI Accession: NM_010921, NP_035051

UniProt: P97436

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Endopeptidase Activity, Positive Regulation of Response to DNA Damage Stimulus