JARID2 antibody (Middle Region)
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- Target See all JARID2 Antibodies
- JARID2 (Jumonji, AT Rich Interactive Domain 2 (JARID2))
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Binding Specificity
- Middle Region
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Reactivity
- Human, Rat, Mouse, Rabbit, Guinea Pig, Dog
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This JARID2 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- NASSSCQSTP RKGKTHKHVH NGHVFNGSSR SAREKEPAHK HRSKEATPGK
- Predicted Reactivity
- Dog: 79%, Guinea Pig: 79%, Human: 79%, Mouse: 100%, Rabbit: 79%, Rat: 79%
- Characteristics
- This is a rabbit polyclonal antibody against Jarid2. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of mouse Jarid2
- Top Product
- Discover our top product JARID2 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 1234 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- JARID2 (Jumonji, AT Rich Interactive Domain 2 (JARID2))
- Alternative Name
- Jarid2 (JARID2 Products)
- Synonyms
- JMJ antibody, Jmj antibody, jumonji antibody, JARID2 antibody, jarid2 antibody, jmj antibody, si:dkey-211c3.1 antibody, Jumonji antibody, jarid2-a antibody, jarid2-b antibody, jarid2.S antibody, jarid2b antibody, jumonji and AT-rich interaction domain containing 2 antibody, jumonji, AT rich interactive domain 2 antibody, jumonji, AT rich interactive domain 2a antibody, jumonji, AT rich interactive domain 2b antibody, jumonji and AT-rich interaction domain containing 2 L homeolog antibody, JARID2 antibody, Jarid2 antibody, jarid2a antibody, jarid2 antibody, jarid2b antibody, jarid2.L antibody
- Background
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Jarid2 is a regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis.Jarid2 acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes.Jarid2 binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells.Jarid2 does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases.Jarid2 also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5.Jarid2 participates in the negative regulation of cell proliferation signaling.
Alias Symbols: AI317256, AU045941, C79929, C79931, Jmj, jumonji
Protein Interaction Partner: Rb1, Suz12, Ewsr1, Ell, Eed, Aebp2, Morc3, Setx, Stk38l, Thrap3, Ice1, Stk38, Bclaf1, Trim35, Rbbp4, Mtf2, Ezh2, Ezh1,
Protein Size: 1234 - Molecular Weight
- 137 kDa
- Gene ID
- 16468
- NCBI Accession
- NM_021878, NP_068678
- UniProt
- Q62315
- Pathways
- Chromatin Binding
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