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JARID2 antibody (Middle Region)

JARID2 Reactivity: Human, Rat, Mouse, Rabbit, Guinea Pig, Dog WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2780036
  • Target See all JARID2 Antibodies
    JARID2 (Jumonji, AT Rich Interactive Domain 2 (JARID2))
    Binding Specificity
    • 15
    • 7
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 44
    • 16
    • 11
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Rat, Mouse, Rabbit, Guinea Pig, Dog
    Host
    • 35
    • 9
    • 2
    • 1
    Rabbit
    Clonality
    • 37
    • 10
    Polyclonal
    Conjugate
    • 22
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This JARID2 antibody is un-conjugated
    Application
    • 33
    • 13
    • 13
    • 12
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    NASSSCQSTP RKGKTHKHVH NGHVFNGSSR SAREKEPAHK HRSKEATPGK
    Predicted Reactivity
    Dog: 79%, Guinea Pig: 79%, Human: 79%, Mouse: 100%, Rabbit: 79%, Rat: 79%
    Characteristics
    This is a rabbit polyclonal antibody against Jarid2. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of mouse Jarid2
    Top Product
    Discover our top product JARID2 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 1234 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    JARID2 (Jumonji, AT Rich Interactive Domain 2 (JARID2))
    Alternative Name
    Jarid2 (JARID2 Products)
    Synonyms
    JMJ antibody, Jmj antibody, jumonji antibody, JARID2 antibody, jarid2 antibody, jmj antibody, si:dkey-211c3.1 antibody, Jumonji antibody, jarid2-a antibody, jarid2-b antibody, jarid2.S antibody, jarid2b antibody, jumonji and AT-rich interaction domain containing 2 antibody, jumonji, AT rich interactive domain 2 antibody, jumonji, AT rich interactive domain 2a antibody, jumonji, AT rich interactive domain 2b antibody, jumonji and AT-rich interaction domain containing 2 L homeolog antibody, JARID2 antibody, Jarid2 antibody, jarid2a antibody, jarid2 antibody, jarid2b antibody, jarid2.L antibody
    Background
    Jarid2 is a regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis.Jarid2 acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes.Jarid2 binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells.Jarid2 does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases.Jarid2 also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5.Jarid2 participates in the negative regulation of cell proliferation signaling.
    Alias Symbols: AI317256, AU045941, C79929, C79931, Jmj, jumonji
    Protein Interaction Partner: Rb1, Suz12, Ewsr1, Ell, Eed, Aebp2, Morc3, Setx, Stk38l, Thrap3, Ice1, Stk38, Bclaf1, Trim35, Rbbp4, Mtf2, Ezh2, Ezh1,
    Protein Size: 1234
    Molecular Weight
    137 kDa
    Gene ID
    16468
    NCBI Accession
    NM_021878, NP_068678
    UniProt
    Q62315
    Pathways
    Chromatin Binding
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