MEFV antibody (N-Term)

Catalog No. ABIN2780331

Product Details anti-MEFV Antibody

Target: MEFV (Mediterranean Fever (MEFV))

Binding Specificity: N-Term

Reactivity: Human, Horse, Rabbit, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MEFV antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MAKTPSDHLL STLEELVPYD FEKFKFKLQN TSVQKEHSRI PRSQIQRARP

Predicted Reactivity: Horse: 85%, Human: 100%, Pig: 77%, Rabbit: 77%

Characteristics: This is a rabbit polyclonal antibody against MEFV. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MEFV

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 781 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MEFV

Target: MEFV (Mediterranean Fever (MEFV))

Alternative Name: MEFV (MEFV Products)

Synonyms: pyrin antibody, MEFV antibody, FMF antibody, MEF antibody, TRIM20 antibody, rfp domain antibody, MEFV, pyrin innate immunity regulator antibody, Mediterranean fever antibody, MEFV antibody, Mefv antibody

Background: MEFV was identified as the gene that when mutated causes Mediterranean fever, a hereditary periodic fever syndrome. MEFV is expressed in granulocytes and myeloid bone marrow precursors. This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: FMF, MEF, MGC126560, MGC126586, TRIM20
Protein Interaction Partner: COG5, PYCARD, PSTPIP1,
Protein Size: 781

Molecular Weight: 86 kDa

Gene ID: 4210

NCBI Accession: NM_000243, NP_000234

UniProt: O15553

Pathways: Positive Regulation of Endopeptidase Activity