SOX9 antibody (C-Term)

Catalog No. ABIN2780338

Product Details anti-SOX9 Antibody

Target: SOX9 (SRY (Sex Determining Region Y)-Box 9 (SOX9))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Rabbit, Dog, Pig, Cow, Zebrafish (Danio rerio), Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOX9 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Sequence: AGQGTGLYST FTYMNPAQRP MYTPIADTSG VPSIPQTHSP QHWEQPVYTQ

Predicted Reactivity: Cow: 86%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against SOX9. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human SOX9

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 509 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-SOX9 antibody (ABIN2780338)

Lau, Lee, Chang: "Conserved sex-specific timing of meiotic initiation during sex differentiation in the protandrous black porgy Acanthopagrus schlegelii." in: Biology of reproduction, Vol. 88, Issue 6, pp. 150, (2013) (PubMed).

Target Details for SOX9

Target: SOX9 (SRY (Sex Determining Region Y)-Box 9 (SOX9))

Alternative Name: SOX9 (SOX9 Products)

Synonyms: CMD1 antibody, CMPD1 antibody, SRA1 antibody, LOC100227849 antibody, 2010306G03Rik antibody, AV220920 antibody, mKIAA4243 antibody, SOX-9 antibody, cmd1 antibody, cmpd1 antibody, sox-9 antibody, sox9 antibody, sox9-a antibody, sox9-b antibody, sox9b antibody, sra1 antibody, SRY-box 9 antibody, transcription factor SOX-9 antibody, SRY (sex determining region Y)-box 9 antibody, SRY box 9 antibody, SRY-box 9 L homeolog antibody, SOX9 antibody, LOC100227849 antibody, Sox9 antibody, sox9.L antibody

Background: SOX9 recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal.The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CMD1, CMPD1, SRA1
Protein Interaction Partner: ZBTB7A, SCX, HERC1, UBC, SOX9, ATP6V1H, ctnnb1-a, RUNX2, SMAD3, SMAD2, EP300, CREB3L4, SPEN, KPNB1, TRAF2, CREBBP, MED12, NR5A1, MAF, HSPA1A, CREB1,
Protein Size: 509

Molecular Weight: 56 kDa

Gene ID: 6662

NCBI Accession: NM_000346, NP_000337

UniProt: P48436

Pathways: EGFR Signaling Pathway, Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development