SOX4 (N-Term) antibody

Details for Product No. ABIN2780469, Supplier: Log in to see
Antigen
  • EVI16
  • AA682046
  • Sox-4
  • sox4
  • wu:fb82f08
  • wu:fq41g10
  • zgc:65850
  • zgc:77392
  • SRY (sex determining region Y)-box 4
  • SRY-box containing gene 4
  • SRY-box containing gene 4a
  • SOX4
  • Sox4
  • sox4a
Epitope
N-Term
20
9
5
5
5
4
4
2
1
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Goat, Guinea Pig, Horse (Equine), Human, Mouse (Murine), Rabbit, Rat (Rattus), Zebrafish
73
24
21
4
4
2
2
1
1
1
1
Host
Rabbit
61
12
Clonality
Polyclonal
Conjugate
Un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
35
22
16
13
12
8
5
3
3
1
Options
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Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human SOX4
Blocking Peptide Blocking peptide for this product available: ABIN984276
Sequence STASTGGKAD DPSWCKTPSG HIKRPMNAFM VWSQIERRKI MEQSPDMHNA
Specificity Peptide immunogen shares 93 % with human SOX11.
Predicted Reactivity Cow: 100%, Dog: 100%, Goat: 91%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
Characteristics This is a rabbit polyclonal antibody against SOX4. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Background SOX4 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. It may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: EVI16
Protein Interaction Partner: TAF5, UBE2I, ELAVL1, TP53, MDM2, EP300, tat, SDCBP,
Protein Size: 474
Molecular Weight 47 kDa
Gene ID 6659
NCBI Accession NM_003107, NP_003098
UniProt Q06945
Research Area Stem Cells, Transcription Factors, Neural Stem Cell marker
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 474 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Supplier Images
Immunohistochemistry (IHC) image for anti-SOX4 (N-Term) antibody (ABIN2780469) anti-SOX4 (N-Term) antibody
Immunohistochemistry (IHC) image for anti-SOX4 (N-Term) antibody (ABIN2780469) anti-SOX4 (N-Term) antibody (Image 2)
Western Blotting (WB) image for anti-SOX4 (N-Term) antibody (ABIN2780469) Host: Rabbit
Target Name: SOX4
Sample Tissue: Human Fetal Heart
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Western Blotting (WB) image for anti-SOX4 (N-Term) antibody (ABIN2780469) Host: Rabbit
Target Name: SOX4
Sample Tissue: Human Fetal Liver
...
Immunohistochemistry (IHC) image for anti-SOX4 (N-Term) antibody (ABIN2780469) Human Heart
Immunohistochemistry (IHC) image for anti-SOX4 (N-Term) antibody (ABIN2780469) Human Testis
Background publications Hoser, Baader, Bösl, Ihmer, Wegner, Sock: "Prolonged glial expression of Sox4 in the CNS leads to architectural cerebellar defects and ataxia." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 20, pp. 5495-505, 2007 (PubMed).