NR2C1 antibody (C-Term)

Catalog No. ABIN2780499

Product Details anti-NR2C1 Antibody

Target: NR2C1 (Nuclear Receptor Subfamily 2, Group C, Member 1 (NR2C1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Dog, Horse, Cow, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NR2C1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: LPALRLMNAT ITEELFFKGL IGNIRIDSVI PHILKMEPAD YNSQIIGHSI

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against NR2C1. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human NR2C1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 603 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for NR2C1

Target: NR2C1 (Nuclear Receptor Subfamily 2, Group C, Member 1 (NR2C1))

Alternative Name: NR2C1 (NR2C1 Products)

Synonyms: TR2 antibody, NR2C1 antibody, dor2 antibody, tr2-11 antibody, xDOR2 antibody, DKFZp468M0512 antibody, si:dkey-183c16.2 antibody, zgc:110672 antibody, 4831444H07Rik antibody, 80.3 antibody, Eenr antibody, Tr2-11 antibody, Tr2 antibody, Psg4 antibody, TR2-11 antibody, PSG9 antibody, nr2c1 antibody, nuclear receptor subfamily 2 group C member 1 antibody, nuclear receptor subfamily 2 group C member 1 S homeolog antibody, nuclear receptor subfamily 2, group C, member 1 antibody, pregnancy specific beta-1-glycoprotein 4 antibody, nuclear receptor subfamily 2 group C member 1 L homeolog antibody, NR2C1 antibody, nr2c1.S antibody, nr2c1 antibody, Nr2c1 antibody, PSG4 antibody, nr2c1.L antibody

Background: The nuclear orphan receptors NR2C1 represses transcription and binds DNA as a homodimer. NR2C1 binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. NR2C1 may function as a negative modulator to suppress androgen receptor function in prostate cancer. NR2C1 may exert an important repressor in regulating ER activity in mammary glands. The nuclear orphan receptors TR2 (NR2C1) and TR4 form a heterodimer that binds to the epsilon and gamma globin promoter DR1 sites
Alias Symbols: TR2, TR2-11
Protein Interaction Partner: PSPC1, MBD3, SIN3A, RCOR1, KDM1A, POLD3, TRIM28, RBM39, MTA2, MTA1, HDAC3, NR2C2, SMARCA4, SFPQ, RBBP7, RBBP4, NONO, HDAC2, HDAC1, HCFC1, DNMT1, CHD4, NUDT3, UBC, PML, HDAC4, NRIP1, AR, ESR1,
Protein Size: 603

Molecular Weight: 67 kDa

Gene ID: 7181

NCBI Accession: NM_003297, NP_003288

UniProt: Q15625

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway