Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) (N-Term) antibody

Details for Product No. ABIN2780604, Supplier: Log in to see
Antigen
  • fc39c11
  • wu:fc39c11
  • zgc:110210
  • AF9
  • YEATS3
  • 2210011H10Rik
  • 2610012I03Rik
  • 3830408D16Rik
  • Af9
  • D4Ertd321e
  • Af-9
  • myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog (Drosophila)
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
  • mllt3
  • MLLT3
  • Mllt3
Epitope
N-Term
32
14
9
8
6
5
4
4
4
4
3
2
2
1
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Rabbit, Rat (Rattus), Zebrafish
83
18
9
8
7
7
6
5
5
3
2
2
2
1
Host
Rabbit
80
3
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
71
38
31
29
21
17
7
4
2
Options
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Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human MLLT3
Blocking Peptide Blocking peptide for this product available: ABIN980124
Sequence MASSCAVQVK LELGHRAQVR KKPTVEGFTH DWMVFVRGPE HSNIQHFVEK
Predicted Reactivity Cow: 100%, Dog: 100%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 86%, Zebrafish: 100%
Characteristics This is a rabbit polyclonal antibody against MLLT3. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name MLLT3 (MLLT3 Antibody Abstract)
Background MLLT3 is a regulator of early erythroid and megakaryocytic cell fate in the human system. Expression of MLLT3 in human CD34+ cells induces acute myeloid, lymphoid, or mixed-lineage leukemia in immunodeficient mice. Translocation t (9,11)(p22,q23), a chromosomal aberration involving MLLT3 is associated with acute leukemias.
Alias Symbols: AF9, FLJ2035, YEATS3
Protein Interaction Partner: CDK9, HSP90B1, EAF1, AFF4, ELL2, MED26, ELL, MLLT3, AFF1, MLLT1, CDK6, CCNT1, CCNT2, APP, Cbx8, DOT1L, PAF1, KMT2A, BCOR, MLLT10, RNF2, AFF3, EEF2, ACACA, PCGF1, ELL3, NIPBL, SIRT1, LRIF1, RBM48, APPBP2, MCM6, PTN, EEF1A1, SGK1,
Protein Size: 568
Molecular Weight 63 kDa
Gene ID 4300
NCBI Accession NM_004529, NP_004520
UniProt P42568
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 568 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Supplier Images
Western Blotting (WB) image for anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) (N-Term) antibody (ABIN2780604) WB Suggested Anti-MLLT3 Antibody Titration: 0.2-1 ug/ml
Positive Control...
Background publications Wei, Wunderlich, Fox, Alvarez, Cigudosa, Wilhelm, Zheng, Cancelas, Gu, Jansen, Dimartino, Mulloy: "Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia." in: Cancer cell, Vol. 13, Issue 6, pp. 483-95, 2008 (PubMed).