MED26 antibody (N-Term)

Catalog No. ABIN2780622

Product Details anti-MED26 Antibody

Target: MED26 (Mediator Complex Subunit 26 (MED26))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Cow, Dog, Rabbit, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MED26 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: TAAPASPQQI RDRLLQAIDP QSNIRNMVAV LEVISSLEKY PITKEALEET

Predicted Reactivity: Cow: 93%, Dog: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against MED26. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MED26

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 600 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MED26

Target: MED26 (Mediator Complex Subunit 26 (MED26))

Alternative Name: MED26 (MED26 Products)

Synonyms: med26 antibody, wu:fe06c07 antibody, wu:fi75a09 antibody, zgc:55993 antibody, CRSP7 antibody, CRSP70 antibody, 5730493L18Rik antibody, AI414941 antibody, AW495270 antibody, Crsp7 antibody, Slc35e1 antibody, crsp7 antibody, mediator of RNA polymerase II transcription subunit 26 antibody, cofactor required for Sp1 transcriptional activation, subunit 7 antibody, mediator complex subunit 26 antibody, mediator complex subunit 26 L homeolog antibody, LOC725023 antibody, crsp7 antibody, MED26 antibody, Med26 antibody, med26.L antibody

Background: MED26 is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-261 AC024075.4 20290-20550 c 262-726 AF104253.1 1-465 727-3184 AK128435.1 1414-3871
Alias Symbols: CRSP7, CRSP70
Protein Interaction Partner: MED19, MED13, MED12, MED21, MED11, TAF8, MED8, MED30, EAF1, MED10, TAF3, MED25, MED28, ICE2, EAF2, MED29, MED9, MED18, MED15, MED31, MED4, AFF4, MED13L, ICE1, CDK19, ELL2, MED16, MED6, MED20, MED7, MED27, MED17, MED23, MED14, ELL, TAF15, TCEB3, TCEA1, TBP
Protein Size: 600

Molecular Weight: 65 kDa

Gene ID: 9441

NCBI Accession: NM_004831, NP_004822

UniProt: O95402

Pathways: Regulation of Lipid Metabolism by PPARalpha