CBFA2T2 antibody (N-Term)

Catalog No. ABIN2780644

Product Details anti-CBFA2T2 Antibody

Target: CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBFA2T2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: AKESGISLKE IQVLARQWKV GPEKRVPAMP GSPVEVKIQS RSSPPTMPPL

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against CBFA2T2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CBFA2T2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 604 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CBFA2T2

Target: CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))

Alternative Name: CBFA2T2 (CBFA2T2 Products)

Synonyms: MTGR1 antibody, A430091M07 antibody, C330013D05Rik antibody, Cbfa2t2h antibody, EHT antibody, ZMYND3 antibody, p85 antibody, XETOR antibody, cbfa2t2-a antibody, CBFA2/RUNX1 translocation partner 2 antibody, core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human) antibody, CBFA2/RUNX1 translocation partner 2 L homeolog antibody, Cbfa2t2 antibody, CBFA2T2 antibody, cbfa2t2.L antibody

Background: In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. CBFA2T2 binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.
Alias Symbols: DKFZp313F2116, EHT, MTGR1, ZMYND3, p85
Protein Interaction Partner: PRDM14, PDP1, CBFA2T2, TCP1, MDFI, RUNX1T1, LBP, APP, ATXN1L, ATN1, RERE, RUNX1, SIN3A, NCOR1, HDAC3, FBXL19, TAL2, NEUROG1, ID3, GTF2E1, WDYHV1, CBFA2T3, NCOR2, CBFB, TAL1,
Protein Size: 604

Molecular Weight: 67 kDa

Gene ID: 9139

NCBI Accession: NM_005093, NP_005084

UniProt: O43439