NCOA2 antibody (N-Term)

Catalog No. ABIN2780788

Product Details anti-NCOA2 Antibody

Target: NCOA2 (Nuclear Receptor Coactivator 2 (NCOA2))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Rabbit, Dog, Cow, Guinea Pig, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NCOA2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MSGMGENTSD PSRAETRKRK ECPDQLGPSP KRNTEKRNRE QENKYIEELA

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against NCOA2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human NCOA2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1464 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-NCOA2 antibody (ABIN2780788)

Strehl, Nebral, König, Harbott, Strobl, Ratei, Struski, Bielorai, Lessard, Zimmermann, Haas, Izraeli: "ETV6-NCOA2: a novel fusion gene in acute leukemia associated with coexpression of T-lymphoid and myeloid markers and frequent NOTCH1 mutations." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 4, pp. 977-83, (2008) (PubMed).

Target Details for NCOA2

Target: NCOA2 (Nuclear Receptor Coactivator 2 (NCOA2))

Alternative Name: NCOA2 (NCOA2 Products)

Synonyms: GRIP1 antibody, KAT13C antibody, NCoA-2 antibody, SRC2 antibody, TIF2 antibody, bHLHe75 antibody, 9530095N19 antibody, D1Ertd433e antibody, GRIP-1 antibody, Grip1 antibody, SRC-2 antibody, TIF-2 antibody, tif2 antibody, wu:fc41a10 antibody, wu:fe26a11 antibody, Tif2 antibody, NCOA2 antibody, XTIF2 antibody, bhlhe75 antibody, grip1 antibody, kat13c antibody, src2 antibody, ncoa2-A antibody, nuclear receptor coactivator 2 antibody, nuclear receptor coactivator 2 S homeolog antibody, NCOA2 antibody, Ncoa2 antibody, ncoa2 antibody, LOC100089041 antibody, ncoa2.S antibody

Background: NCOA2 is the transcriptional coactivator for steroid receptors and nuclear receptors. NCOA2 is the coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). NCOA2 is required with NCOA1 to control energy balance
Alias Symbols: GRIP1, KAT13C, MGC138808, NCoA-2, TIF2, SRC2, bHLHe75
Protein Interaction Partner: VDR, PSMB9, PPARG, ESR1, PML, UBC, TP53, TAF9, Pias3, tat, THRB, NR3C1, EP300, NR1I2, RXRA, RARA, CREBBP, AHR, KANK2, MAGEA11, NCOA1, HHV8GK18_gp81, ESR2, PGR, SUMO2, CAD, ATR, HSPA2, CC2D1A, UBR5, TBK1, WDHD1, USO1, STAT6, NCOA3, THRA, CDK4, CCND3, EID1,
Protein Size: 1464

Molecular Weight: 159 kDa

Gene ID: 10499

NCBI Accession: NM_006540, NP_006531

UniProt: Q15596

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Regulation of Lipid Metabolism by PPARalpha, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling