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TRIM32 antibody (N-Term)

TRIM32 Reactivity: Human, Mouse, Rat, Dog, Cow, Rabbit, Horse, Guinea Pig WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2780865
  • Target See all TRIM32 Antibodies
    TRIM32 (Tripartite Motif Containing 32 (TRIM32))
    Binding Specificity
    • 16
    • 7
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 29
    • 24
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    Human, Mouse, Rat, Dog, Cow, Rabbit, Horse, Guinea Pig
    Host
    • 35
    • 5
    • 1
    Rabbit
    Clonality
    • 39
    • 2
    Polyclonal
    Conjugate
    • 19
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TRIM32 antibody is un-conjugated
    Application
    • 32
    • 14
    • 13
    • 13
    • 9
    • 6
    • 6
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    MAAAAASHLN LDALREVLEC PICMESFTEE QLRPKLLHCG HTICRQCLEK
    Predicted Reactivity
    Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 93%, Mouse: 93%, Rabbit: 93%, Rat: 93%
    Characteristics
    This is a rabbit polyclonal antibody against TRIM32. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Protein A purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human TRIM32
    Top Product
    Discover our top product TRIM32 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 653 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Streich, Ronchi, Connick, Haas: "Tripartite motif ligases catalyze polyubiquitin chain formation through a cooperative allosteric mechanism." in: The Journal of biological chemistry, Vol. 288, Issue 12, pp. 8209-21, (2013) (PubMed).

    Kudryashova, Wu, Havton, Spencer: "Deficiency of the E3 ubiquitin ligase TRIM32 in mice leads to a myopathy with a neurogenic component." in: Human molecular genetics, Vol. 18, Issue 7, pp. 1353-67, (2009) (PubMed).

  • Target
    TRIM32 (Tripartite Motif Containing 32 (TRIM32))
    Alternative Name
    TRIM32 (TRIM32 Products)
    Synonyms
    BBS11 antibody, HT2A antibody, LGMD2H antibody, TATIP antibody, 1810045E12Rik antibody, 3f3 antibody, Zfp117 antibody, tripartite motif containing 32 antibody, tripartite motif-containing 32 antibody, TRIM32 antibody, trim32 antibody, Trim32 antibody
    Background
    TRIM32 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. TRIM32 localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes.The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes.
    Alias Symbols: HT2A, BBS11, TATIP, LGMD2H
    Protein Interaction Partner: PTPN11, PDE9A, PTCD2, CLIP4, KCTD9, UBQLN1, TRIM32, RABAC1, ABI2, SCGB1A1, UBE2E1, UBE2D1, UBC, TP53, SDCBP, UBE2U, SYT6, MYCN, CEP250, CUL3, GPRASP2, GLIS2, YWHAB, TP73, UBE2D3, UBE2D2, HSP90AA1, SFN, YWHAQ, YWHAZ, YWHAH, YWHAG, YWHAE, NOTCH1, UBD, TOP1,
    Protein Size: 653
    Molecular Weight
    72 kDa
    Gene ID
    22954
    NCBI Accession
    NM_012210, NP_036342
    UniProt
    Q13049
    Pathways
    Negative Regulation of intrinsic apoptotic Signaling
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