ABCC3 antibody (Middle Region)

Catalog No. ABIN2781505

Product Details anti-ABCC3 Antibody

Target: ABCC3 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 3 (ABCC3))

Binding Specificity: Middle Region

Reactivity: Human, Rat, Dog, Guinea Pig, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABCC3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: KVHMKGSVAY VPQQAWIQNC TLQENVLFGK ALNPKRYQQT LEACALLADL

Predicted Reactivity: Dog: 77%, Guinea Pig: 79%, Horse: 79%, Human: 100%, Pig: 86%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against ABCC3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ABCC3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1527 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-ABCC3 antibody (ABIN2781505)

Jeong, Kim, Shin, Park, Oh, Kim, Moon, Choi, Jeong, Shin, Kim: "Increased serum bile acid concentration following low-dose chronic administration of thioacetamide in rats, as evidenced by metabolomic analysis." in: Toxicology and applied pharmacology, Vol. 288, Issue 2, pp. 213-22, (2015) (PubMed).

Target Details for ABCC3

Target: ABCC3 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 3 (ABCC3))

Alternative Name: ABCC3 (ABCC3 Products)

Synonyms: ABC31 antibody, EST90757 antibody, MLP2 antibody, MOAT-D antibody, MRP3 antibody, cMOAT2 antibody, 1700019L09Rik antibody, Mlp2 antibody, Mrp3 antibody, ATP binding cassette subfamily C member 3 antibody, ATP-binding cassette, sub-family C (CFTR/MRP), member 3 antibody, ABCC3 antibody, Abcc3 antibody

Background: ABCC3 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined, however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described, however, not all variants have been fully characterized. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined, however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described, however, not all variants have been fully characterized. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ABC31, EST90757, MLP2, MOAT-D, MRP3, cMOAT2
Protein Interaction Partner: UBC, MLH1,
Protein Size: 1527

Molecular Weight: 168 kDa

Gene ID: 8714

NCBI Accession: NM_003786, NP_003777

UniProt: O15438