ABCA7 antibody (Middle Region)

Catalog No. ABIN2781526

Product Details anti-ABCA7 Antibody

Target: ABCA7 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 7 (ABCA7))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABCA7 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: DTQTRHLSGG MQRKLSVAIA FVGGSRVVIM DEPTAGVDPA SRRGIWELLL

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against Abca7. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Mouse

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 2159 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-ABCA7 antibody (ABIN2781526)

Bamji-Mirza, Li, Najem, Liu, Walker, Lue, Stupak, Chan, Li, Ghani, Yang, Rogaeva, Zhang: "Genetic Variations in ABCA7 Can Increase Secreted Levels of Amyloid-β40 and Amyloid-β42 Peptides and ABCA7 Transcription in Cell Culture Models." in: Journal of Alzheimer's disease : JAD, Vol. 53, Issue 3, pp. 875-92, (2016) (PubMed).

Target Details for ABCA7

Target: ABCA7 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 7 (ABCA7))

Alternative Name: Abca7 (ABCA7 Products)

Synonyms: ABCX antibody, Abc51 antibody, ABCA-SSN antibody, ABCA7 antibody, ATP-binding cassette, sub-family A (ABC1), member 7 antibody, ATP binding cassette subfamily A member 7 antibody, ATP-binding cassette sub-family A member 7 antibody, Abca7 antibody, ABCA7 antibody, LOC100088822 antibody

Background: Abca7 plays a role in phagocytosis by macrophages of apoptotic cells.Abca7 binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. Abca7 may also mediate cholesterol efflux. Abca7 may regulate cellular ceramide homeostasis during keratinocytes differentiation.
Alias Symbols: ABCX, Abc51
Protein Size: 2159

Molecular Weight: 237 kDa

Gene ID: 27403

NCBI Accession: NM_013850, NP_038878

UniProt: Q91V24