ABCG5 antibody (Middle Region)

Catalog No. ABIN2781532

Product Details anti-ABCG5 Antibody

Target: ABCG5 (ATP-Binding Cassette, Sub-Family G (WHITE), Member 5 (ABCG5))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABCG5 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: CGYPCPEHSN PFDFYMDLTS VDTQSKEREI ETSKRVQMIE SAYKKSAICH

Predicted Reactivity: Cow: 86%, Dog: 86%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 86%, Rabbit: 86%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against ABCG5. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ABCG5

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 651 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ABCG5

Target: ABCG5 (ATP-Binding Cassette, Sub-Family G (WHITE), Member 5 (ABCG5))

Alternative Name: ABCG5 (ABCG5 Products)

Synonyms: DDBDRAFT_0205617 antibody, DDBDRAFT_0215344 antibody, DDB_0205617 antibody, DDB_0215344 antibody, STSL antibody, AW112016 antibody, cmp antibody, sterolin-1 antibody, trac antibody, ATP binding cassette subfamily G member 5 antibody, ATP-binding cassette, sub-family G (WHITE), member 5 antibody, ABC transporter G family protein antibody, ABCG5 antibody, abcg5 antibody, abcG5 antibody, Abcg5 antibody

Background: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia.
Alias Symbols: STSL
Protein Interaction Partner: Dlg4, ABCG8,
Protein Size: 651

Molecular Weight: 72 kDa

Gene ID: 64240

NCBI Accession: NM_022436, NP_071881

UniProt: Q9H222

Pathways: Lipid Metabolism